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Gene Review

Corin  -  corin

Mus musculus

Synonyms: AV273130, Atrial natriuretic peptide-converting enzyme, Crn, Low density lipoprotein receptor-related protein 4, Lrp4, ...
 
 
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Disease relevance of Corin

 

High impact information on Corin

  • Corin is a cardiac transmembrane serine protease that has been shown to process pro-ANP in vitro, but its physiological importance had not been established [1].
  • Using radiotelemetry to assess blood pressure, we find that Cor-/- mice have spontaneous hypertension as compared with WT mice, and it is enhanced after dietary salt loading [1].
  • Here, we show that corin-deficient (Cor-/-) mice develop normally during embryogenesis and survive to postnatal life [1].
  • Corin is a type II transmembrane serine protease abundantly expressed in the heart [2].
  • In contrast, overexpression of active site mutant corin S985A or transfection of oligonucleotide small interfering RNA duplexes directed against the mouse corin gene completely inhibited the processing of recombinant pro-ANP in HL-5 cells [2].
 

Chemical compound and disease context of Corin

 

Biological context of Corin

  • Both corin genes contain 22 exons and span >200 kb [4].
  • Transfection experiments with reporter gene constructs driven by the human or murine corin 5'-flanking region indicated that the sequences from -405 to -15 in human and from -646 to -77 in mouse are sufficient to promote high levels of gene expression in murine cardiomyocytes [4].
  • The unique domain structure and specific embryonic expression pattern suggest that corin may have a function in cell differentiation during development [5].
  • Tissue distribution as well as regulation of corin mRNA expression in the atria were determined by RT-PCR and RNase protection assay [6].
 

Anatomical context of Corin

  • In mice, corin mRNA was detected by in situ hybridization in the cardiac myocytes of the embryonic heart as early as embryonic day (E) 9 [5].
  • Corin mRNA expression was decreased in both atria in shunt animals [right atrium: control 0.638 +/- 0.004 arbitrary units (AU), shunt 0.566 +/- 0.014 AU, P < 0.001; left atrium: control 0.564 +/- 0.009 AU, shunt 0.464 +/- 0.009 AU, P < 0.001] [6].
  • Expression of low density lipoprotein receptor-related protein 4 (Lrp4) gene in the mouse germ cells [7].
  • The low density lipoprotein receptor-related protein 4 gene (Lrp4) was identified by subtractive screening of cDNAs of the migratory primordial germ cells (PGCs) of E8.5-9.5 embryo and E3.5 blastocysts [7].
 

Associations of Corin with chemical compounds

  • Corin is a serin protease with pro-ANP-converting properties and may be the rate-limiting enzyme in ANP release [6].
 

Analytical, diagnostic and therapeutic context of Corin

References

  1. Hypertension in mice lacking the proatrial natriuretic peptide convertase corin. Chan, J.C., Knudson, O., Wu, F., Morser, J., Dole, W.P., Wu, Q. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes. Wu, F., Yan, W., Pan, J., Morser, J., Wu, Q. J. Biol. Chem. (2002) [Pubmed]
  3. "Corination" of the proANP converting enzyme. Potter, L.R. Cell metabolism. (2005) [Pubmed]
  4. Genomic structures of the human and murine corin genes and functional GATA elements in their promoters. Pan, J., Hinzmann, B., Yan, W., Wu, F., Morser, J., Wu, Q. J. Biol. Chem. (2002) [Pubmed]
  5. Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart. Yan, W., Sheng, N., Seto, M., Morser, J., Wu, Q. J. Biol. Chem. (1999) [Pubmed]
  6. Rat corin gene: molecular cloning and reduced expression in experimental heart failure. Langenickel, T.H., Pagel, I., Buttgereit, J., Tenner, K., Lindner, M., Dietz, R., Willenbrock, R., Bader, M. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  7. Expression of low density lipoprotein receptor-related protein 4 (Lrp4) gene in the mouse germ cells. Yamaguchi, Y.L., Tanaka, S.S., Kasa, M., Yasuda, K., Tam, P.P., Matsui, Y. Gene Expr. Patterns (2006) [Pubmed]
 
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