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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

HGTX  -  CG13475 gene product from transcript...

Drosophila melanogaster

Synonyms: CG13475, CG4745, Dmel\CG13475, Nk6, Nkx6, ...
 
 
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High impact information on HGTX

  • Furthermore, Nkx6 is necessary for the expression of the neural adhesion molecule Fasciclin III in Nkx6-positive motoneurons [1].
  • Conversely, ectopic Zfh1 induces a subset of interneurons--all normally expressing two or more "ventral motor neuron transcription factors" (e.g. Islet, Hb9, Nkx6, Lim3)--to project laterally and exit the CNS [2].
  • In vnd mutants, head neuroectoderm Nk6 expression is abolished where it is normally co-expressed with vnd [3].
 

Biological context of HGTX

 

Other interactions of HGTX

  • We show genetically that Nk6 is positively regulated, directly or indirectly, by vnd in brain precursors [3].

References

  1. Drosophila homeodomain protein Nkx6 coordinates motoneuron subtype identity and axonogenesis. Broihier, H.T., Kuzin, A., Zhu, Y., Odenwald, W., Skeath, J.B. Development (2004) [Pubmed]
  2. Zfh1, a somatic motor neuron transcription factor, regulates axon exit from the CNS. Layden, M.J., Odden, J.P., Schmid, A., Garces, A., Thor, S., Doe, C.Q. Dev. Biol. (2006) [Pubmed]
  3. Nk6, a novel Drosophila homeobox gene regulated by vnd. Uhler, J., Garbern, J., Yang, L., Kamholz, J., Mellerick, D.M. Mech. Dev. (2002) [Pubmed]
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