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Gene Review

Porcn  -  porcupine homolog (Drosophila)

Mus musculus

Synonyms: 2410004O13Rik, AW045557, DXHXS7465e, Mporc, Mporc-a, ...
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High impact information on Porcn

  • Mporc mRNA is differentially expressed during embryogenesis and in various adult tissues, demonstrating that the alternative splicing is regulated to synthesize the specific types of Mporc [1].
  • Interestingly, all Mporc types can substitute for Porc, as they are able to rescue the phenotypes of Drosophila porc embryos [1].

Biological context of Porcn


  1. The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. Tanaka, K., Okabayashi, K., Asashima, M., Perrimon, N., Kadowaki, T. Eur. J. Biochem. (2000) [Pubmed]
  2. Misexpression of mouse porcupine isoforms modulates the differentiation of P19 embryonic carcinoma cells. Tanaka, K., Kitagawa, Y., Kadowaki, T. Cell Biol. Int. (2003) [Pubmed]
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