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Gene Review:

Porcn - porcupine homolog (Drosophila)

Mus musculus

Synonyms: 2410004O13Rik, AW045557, DXHXS7465e, Mporc, Mporc-a, ...

Tanaka, K. et al., Tanaka, K. et al.

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High impact information on Porcn

Mporc mRNA is differentially expressed during embryogenesis and in various adult tissues, demonstrating that the alternative splicing is regulated to synthesize the specific types of Mporc [1].
Interestingly, all Mporc types can substitute for Porc, as they are able to rescue the phenotypes of Drosophila porc embryos [1].

Biological context of Porcn

In contrast to Drosophila, vertebrates generate four different porc mRNAs (A-D) by alternative splicing [2].

References

The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. Tanaka, K., Okabayashi, K., Asashima, M., Perrimon, N., Kadowaki, T. Eur. J. Biochem. (2000) [Pubmed]
Misexpression of mouse porcupine isoforms modulates the differentiation of P19 embryonic carcinoma cells. Tanaka, K., Kitagawa, Y., Kadowaki, T. Cell Biol. Int. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

PORCN_ANOGA	Anopheles gambiae str. PEST
PORCN	Bos taurus
PORCN	Canis lupus familiaris
porcnl	Danio rerio
PORCN	Homo sapiens
PORCN	Pan troglodytes
Porcn	Rattus norvegicus
porcn	Xenopus (Silurana) tropicalis

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