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Gene Review:

Cks1b - CDC28 protein kinase 1b

Mus musculus

Synonyms: 2410005G18Rik, 2610005D03Rik, AA407784, CKS-1, Cks1, ...

Lin, R. et al., Zhang, Y. et al., Donovan, P.J. et al.

Donovan, Reed,

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Disease relevance of Cks1b

EB1089 treatment repressed expression of mRNAs encoding the F-box protein p45(SKP2), a marker of poor head and neck cancer prognosis, and the cyclin kinase subunit CKS1, which is essential for targeting p45(SKP2) to p27(KIP1) [1].

High impact information on Cks1b

FGF-dependent activation of FGFR tyrosine kinases induces FRS2 phosphorylation, causes release of Cks1 from FRS2, and promotes degradation of p27(Kip1) in 3T3 cells [2].
Germline exclusion of Cks1 in the mouse reveals a metaphase I role for Cks proteins in male and female meiosis [3].

References

Inhibition of F-Box protein p45(SKP2) expression and stabilization of cyclin-dependent kinase inhibitor p27(KIP1) in vitamin D analog-treated cancer cells. Lin, R., Wang, T.T., Miller, W.H., White, J.H. Endocrinology (2003) [Pubmed]
Direct cell cycle regulation by the fibroblast growth factor receptor (FGFR) kinase through phosphorylation-dependent release of Cks1 from FGFR substrate 2. Zhang, Y., Lin, Y., Bowles, C., Wang, F. J. Biol. Chem. (2004) [Pubmed]
Germline exclusion of Cks1 in the mouse reveals a metaphase I role for Cks proteins in male and female meiosis. Donovan, P.J., Reed, S.I. Cell Cycle (2003) [Pubmed]

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AgaP_AGAP003796	Anopheles gambiae str. PEST
CKS1B	Bos taurus
cks-1	Caenorhabditis elegans
CKS1B	Canis lupus familiaris
cks1b	Danio rerio
Cks85A	Drosophila melanogaster
CKS1B	Gallus gallus
CKS1B	Homo sapiens
CKS1B	Macaca mulatta
CKS1B	Pan troglodytes
Cks1b	Rattus norvegicus
cks1b	Xenopus (Silurana) tropicalis

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