High impact information on Actr1a

• Monomeric actin-RPV produced in in vitro folding reactions cocycles efficiently with native brain actin, while in vitro folded gamma-tubulin binds to polymerized microtubules in a manner consistent with interaction with microtubule ends [1].
• The present study explores the effects of pyruvate, aspartate and citrate on improving the abnormalities observed in the Ctrn(-/-) liver [2].
• RESULTS: Pyruvate infusion lowered the L/P ratio and corrected the deficit in ureogenesis in the Ctrn(-/-) liver [2].
• Phenazine methosulfate, a cytosolic oxidant, also improved the rate of ureogenesis in the Ctrn(-/-) liver and led to a fall in the L/P ratio [2].
• The deduced amino acid sequence was identical with that of human alpha-Arp1 [3].

Anatomical context of Actr1a

• Northern blot analysis showed that the alpha-Arp1 mRNA corresponding to the longer cDNA is transcribed not only in various non-muscle tissues but also in muscle tissues, while the transcript corresponding to the shorter one becomes expressed only in skeletal muscle as development progresses [3].

Associations of Actr1a with chemical compounds

• The addition of aspartate or citrate did not change either the rate of ureogenesis or the L/P ratio in the Ctrn(-/-) liver [2].

References