High impact information on Cyhr1

• Moreover, we found that Chrp binds to the carbohydrate-recognition domain (CRD) of hamster galectin-3 and not to the N-terminal domain carrying the proline- and glycine-rich repeats characteristic of galectin-3 and absent in other galectins [1].
• However, galectin-1 does not bind to Chrp, although its CRD is homologous to the galectin-3 CRD [1].
• Specificity of interactions of galectin-3 with Chrp, a cysteine- and histidine-rich cytoplasmic protein [1].
• Earlier work described the cloning of a gene from murine 3T3 cells encoding a cytoplasmic protein Chrp containing a cysteine- and histidine-rich motif characteristic of Zn-finger proteins [1].
• Finally, we report that galectin-3, in a complex with Chrp, binds to laminin in surface plasmon resonance experiments with similar kinetics and affinity as it does in the free state [1].

References