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Gene Review

Rgs7  -  regulator of G-protein signaling 7

Rattus norvegicus

Synonyms: RGS7, Regulator of G-protein signaling 7
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High impact information on Rgs7

  • Co-expression in COS-7 cells of Gbeta(5) dramatically increased the protein level of RGS7 and vice versa, indicating that cells maintain Gbeta(5):RGS stoichiometry in a manner similar to Gbetagamma complexes [1].
  • However, in transfected cells, RGS7 and Gbeta(5)-RGS7 inhibited Galpha(q)-mediated Ca(2+) response to muscarinic M3 receptor activation [1].
  • In situ hybridization study revealed that RGS7 mRNA is predominantly expressed in Golgi cells within granule cell layer of cerebellar cortex [2].
  • In ventromedial hypothalamus, RGS4 mRNA content was increased 24 h following chronic ECS, whereas RGS7 mRNA levels were only increased 24 h following an acute ECS [3].
  • At 24 h following chronic ECS, RGS7, -8 and -10 mRNA levels were decreased in the granule cell layer, and RGS7 and -8 mRNA levels were decreased in the pyramidal cell layers [3].

Biological context of Rgs7


Anatomical context of Rgs7

  • Spinal cord injury induces expression of RGS7 in microglia/macrophages in rats [5].
  • Here we confirm the expression of RGS7 in spinal neurons and show as a novel finding that following an experimental spinal cord injury in rats, expression of RGS7 is induced in a subpopulation of other cells [5].
  • To rule out interference from the adjacent neurons and confirm the presence of RGS7-Gbeta5 complex in inflammatory cells, we performed immunocytochemistry, RT-PCR, Western blot, and immunoprecipitation using microglial (BV2) and peripheral macrophage (RAW) cell lines [5].
  • Dual immunofluorescence labeling studies with the two protein-specific antibodies indicated a cellular selectivity in the colocalization between RGS7 and Galphaq/11 within many discrete brain regions, such as the superficial cortical layer I, hilus area of the hippocampal formation, and cerebellar Golgi cells [6].
  • RGS7 immunoreactivity was observed in cortical layers I-VI, being most intense in the neuropil of layer I [6].

Associations of Rgs7 with chemical compounds


Other interactions of Rgs7

  • Our findings show that RGS7-Gbeta5 complex is expressed in immunocompetent cells such as resident microglia and peripheral macrophages following spinal cord injury [5].
  • Expression of RGS7 mRNA and protein are nearly undetectable in non-stimulated BV2 and RAW cells, but remarkably increased after stimulation with LPS or TNF-alpha In addition, RGS7-positive cells were also found in the perinodular rim in the rat spleen [5].

Analytical, diagnostic and therapeutic context of Rgs7

  • Here, we examined the behavior of Gbeta(5), RGS7, RGS9, and Galpha in tissue extracts using immunoprecipitation and conventional chromatography [1].
  • Immunofluorescent confocal microscopy using a series of cell specific antibodies identified these RGS7 positive cells as activated microglia and/or invading peripheral macrophages [5].
  • Our results provide novel information on the region- and cell-specific pattern of distribution of RGS7 with the transmembrane signal transducer, Galphaq/11 [6].


  1. Complexes of the G protein subunit gbeta 5 with the regulators of G protein signaling RGS7 and RGS9. Characterization in native tissues and in transfected cells. Witherow, D.S., Wang, Q., Levay, K., Cabrera, J.L., Chen, J., Willars, G.B., Slepak, V.Z. J. Biol. Chem. (2000) [Pubmed]
  2. RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currents. Saitoh, O., Kubo, Y., Odagiri, M., Ichikawa, M., Yamagata, K., Sekine, T. J. Biol. Chem. (1999) [Pubmed]
  3. Regulation of regulators of G protein signaling mRNA expression in rat brain by acute and chronic electroconvulsive seizures. Gold, S.J., Heifets, B.D., Pudiak, C.M., Potts, B.W., Nestler, E.J. J. Neurochem. (2002) [Pubmed]
  4. RGS7 complex formation and colocalization with the Gbeta5 subunit in the adult rat brain and influence on Gbeta5gamma2-mediated PLCbeta signaling. Liang, J.J., Chen, H.H., Jones, P.G., Khawaja, X.Z. J. Neurosci. Res. (2000) [Pubmed]
  5. Spinal cord injury induces expression of RGS7 in microglia/macrophages in rats. Hausmann, O.N., Hu, W.H., Keren-Raifman, T., Witherow, D.S., Wang, Q., Levay, K., Frydel, B., Z Slepak, V., R Bethea, J. Eur. J. Neurosci. (2002) [Pubmed]
  6. Immunohistochemical distribution of RGS7 protein and cellular selectivity in colocalizing with Galphaq proteins in the adult rat brain. Khawaja, X.Z., Liang, J.J., Saugstad, J.A., Jones, P.G., Harnish, S., Conn, P.J., Cockett, M.I. J. Neurochem. (1999) [Pubmed]
  7. A region-specific increase in Galphaq and Galpha11 proteins in brains of rats during cocaine withdrawal. Carrasco, G.A., Zhang, Y., Damjanoska, K.J., D'Souza, D.N., Garcia, F., Battaglia, G., Muma, N.A., Van de Kar, L.D. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
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