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Gene Review:

Elovl1 - elongation of very long chain fatty acids...

Mus musculus

Synonyms: 3-keto acyl-CoA synthase Elovl1, AA407424, BB151133, ELOVL FA elongase 1, ELOVL fatty acid elongase 1, ...

Jakobsson, A. et al., Asadi, A. et al., Tvrdik, P. et al.

Tvrdik, Westerberg, Silve, Asadi, Jakobsson, Cannon, Loison, Jacobsson,

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Disease relevance of Elovl1

To elucidate the structure and regulation of the Elovl gene we have isolated a lambda phage genomic DNA clone containing the entire mouse gene and found that Elovl1 consists of eight exons that are dispersed over 5.4 kb of genomic sequence [1].

High impact information on Elovl1

The Ssc1 gene appears to be ubiquitously expressed, whereas Ssc2 and Cig30 show a restricted expression pattern [2].
In cultured brown adipocytes, a mixture of norepinephrine, dexamethasone, and the PPARalpha ligand Wy-14643, which rendered the adipocytes a high oxidative state, was required for substantial induction of Elovl3 expression, whereas the same treatment suppressed Elovl1 mRNA levels [3].

References

Elovl1 and p55Cdc genes are localized in a tail-to-tail array and are co-expressed in proliferating cells. Asadi, A., Jörgensen, J., Jacobsson, A. J. Biol. Chem. (2002) [Pubmed]
Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids. Tvrdik, P., Westerberg, R., Silve, S., Asadi, A., Jakobsson, A., Cannon, B., Loison, G., Jacobsson, A. J. Cell Biol. (2000) [Pubmed]
Differential regulation of fatty acid elongation enzymes in brown adipocytes implies a unique role for Elovl3 during increased fatty acid oxidation. Jakobsson, A., Jörgensen, J.A., Jacobsson, A. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]

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AgaP_AGAP004373	Anopheles gambiae str. PEST
ELOVL1	Bos taurus
ELOVL1	Canis lupus familiaris
elovl1a	Danio rerio
elovl1b	Danio rerio
CG31522	Drosophila melanogaster
ELOVL1	Gallus gallus
ELOVL1	Homo sapiens
ELOVL1	Macaca mulatta
ELOVL1	Pan troglodytes
Elovl1	Rattus norvegicus
elovl1	Xenopus (Silurana) tropicalis

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