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Atp6ap1  -  ATPase, H+ transporting, lysosomal...

Mus musculus

Synonyms: 16A, AC45, AI316502, AW108110, Atp6ip1, ...
 
 
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Disease relevance of Atp6ap1

  • Dengue virus (DV) induces T lymphocytes of the spleen to produce a cytotoxic factor (CF) that induces a subpopulation of macrophages (M phi) to produce a soluble cytotoxin (CF2) [1].
  • Monoclonal antibody (MAb) CF2, which binds to the fusion peptide of influenza A virus hemagglutinin (HA) (amino acids (aa) 1-35 of the N-terminus of the light chain of HA), inhibited the fusion activity of HA [2].
 

Psychiatry related information on Atp6ap1

  • Further, ssumazenil (2 mg/kg), a benzodiazepine receptor antagonist and FG 7142 (10 mg/kg), an inverse agonist, when co-administered with BR-16A (100 mg/kg), showed no significant reversal on pentobarbitone-induced hypnosis, locomotor activity and social isolation-induced antinociception compared with their effects per se [3].
 

High impact information on Atp6ap1

  • We have cloned representatives of the EcoRI-Bg1II gene family in Charon 16A and studied their structure and organization within the genome [4].
  • Using the anti-CD45RB mAb 16A as marker for naive and memory CD4 T cells, we show that B cells activated by LPS and by poly-I:C can provide co-stimulatory signal to both naive and memory CD4 T cells [5].
  • In both the absence and presence of F6/16A the initial uptake of single viral particles was mediated by coated pits, and started within 30 s of warming the cells to 37 degrees C. Viral particles later appeared in fully or partially coated vesicles and later in uncoated prelysosomal endocytic vacuoles before degradation in lysosomes [6].
  • When the same samples were analyzed using the 4.7 T imaging magnet, the CF3 and CF2 fluorine peaks were readily identifiable in the parent EF5 sample but no fluorine signal could be detected from EF5 bound to KHT tumor cells [7].
  • In the present study it has been observed that CF induces mouse spleen and peritoneal macrophages to produce a cytotoxin (CF2) as has been revealed by DEAE-cellulose chromatography [8].
 

Chemical compound and disease context of Atp6ap1

  • The role of calcium ions (Ca2+) in the cytotoxic activity of the dengue type 2 virus (DV)-induced macrophage (M phi) cytotoxin (CF2) was investigated in the present study [9].
 

Biological context of Atp6ap1

  • Thus, these findings indicate that DV infection impaired the generation of respiratory burst, and the impairment appeared to be mediated by two DV-induced cytokines (CF/CF2) [10].
  • Thus, the presence of Ca2+ is obligatory for the cytotoxic activity of CF2 and cell death is associated with increased intracellular Ca2+ [9].
  • The present study was undertaken to investigate the effect of CF2 on capillary permeability [11].
  • Exploiting the fusion-inhibition activity of MAb CF2 the effect of this antibody on the virus replication in vitro was followed using both the wt virus and the amantadine resistant mutant Ab4 [2].
 

Anatomical context of Atp6ap1

  • CF2 kills most of the macrophages and some of the T cells, as observed with CF [8].
  • We have observed earlier that dengue type 2 virus-induced cytotoxic factor (CF) induces macrophages to produce a cytotoxin (CF2) which kills mainly the macrophages, some of the T lymphocytes and has no effect on B-lymphocytes of normal mouse spleen [12].
  • CF2 activity could not be observed in the serum or peritoneal fluid though it is produced in peritoneal M phi [13].
  • In the present study, it has been observed that pretreatment of target cells with cell plasma membrane stabilizers--2,4-dinitrophenol, ouabain and reduced glutathione--prevents the cytotoxicity of CF and blocks the production of CF2, but does not abolish the cytotoxic effect of the latter [14].
  • Our earlier studies reported that the cytotoxic factor (CF) produced in the spleen of dengue virus type 2-infected mice killed the lymphoid cells of many species of animals and induced normal mouse splenic and peritoneal macrophages to produce a cytotoxin (CF2) [14].
 

Associations of Atp6ap1 with chemical compounds

  • The findings of the present study thus demonstrate that CF2 induces production of NO2- in the spleen cells in a CA(2+)-dependent manner which may be a mechanism of target cell killing [15].
  • This indicated that O2- production is necessary for the cytotoxic activity of CF2 [16].
  • The findings show that CF2 prepared in Ca(2+)-free medium had no cytotoxic activity on normal mouse spleen cells suspended in Ca(2+)-free medium but killed the cells suspended in the medium with Ca2+ [9].
  • Substitution with calcium chloride restored the cytotoxic activity of CF2 the optimal dose being 10(-4) M concentration [9].
  • The cytotoxic activity of CF2 as well as the CF2-induced influx of 45Ca was inhibited by treatment of the target cell with the calcium channel blocking drugs verapamil and nifedipine [9].
 

Analytical, diagnostic and therapeutic context of Atp6ap1

  • By enzyme-linked immunosorbent assay (ELISA), the reactivities of horseradish peroxidase (HRP)-conjugated MAbs 16A and 29A with homologous CAEV-63 SU were <10% of that of HRP-conjugated MAb 74A [17].
  • No reduction of replication of wt virus and a low reduction of replication of Ab4 mutant (by about 20%) was detected by radioimmunoassay after preincubation of the virus with a high concentration of MAb CF2 at room temperature [2].
  • The present study was undertaken to investigate the effect of dengue type 2 virus (DV) and DV-induced cytokines (CF and CF2) on T lymphocyte subpopulations of spleen by flow cytometry [18].

References

  1. Variable effects of dengue virus-induced cytotoxic factors on different subpopulations of macrophages. Chaturvedi, U.C., Nagar, R., Gulati, L., Mathur, A. Immunology (1987) [Pubmed]
  2. A monoclonal antibody specific to the HA2 glycoprotein of influenza A virus hemagglutinin that inhibits its fusion activity reduces replication of the virus. Varecková, E., Wharton, S.A., Mucha, V., Gocník, M., Kostolanský, F. Acta Virol. (2003) [Pubmed]
  3. Protective effect of BR-16A, a polyherbal preparation against social isolation stress: possible GABAergic mechanism. Kumar, A., Kulkarni, S.K. Phytotherapy research : PTR. (2006) [Pubmed]
  4. Structure and organization of the highly repeated and interspersed 1.3 kb EcoRI-Bg1II sequence family in mice. Heller, R., Arnheim, N. Nucleic Acids Res. (1980) [Pubmed]
  5. Microbial induction of co-stimulatory activity for CD4 T-cell growth. Liu, Y., Janeway, C.A. Int. Immunol. (1991) [Pubmed]
  6. Flavivirus infection enhancement in macrophages: an electron microscopic study of viral cellular entry. Gollins, S.W., Porterfield, J.S. J. Gen. Virol. (1985) [Pubmed]
  7. Utility of 19F MRS detection of the hypoxic cell marker EF5 to assess cellular hypoxia in solid tumors. Salmon, H.W., Siemann, D.W. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (2004) [Pubmed]
  8. Dengue virus-induced cytotoxic factor induces macrophages to produce a cytotoxin. Gulati, L., Chaturvedi, U.C., Mathur, A. Immunology (1983) [Pubmed]
  9. Obligatory role of Ca2+ in the cytotoxic activity of dengue virus-induced cytotoxin. Dhawan, R., Chaturvedi, U.C., Khanna, M., Mathur, A., Tekwani, B.L., Pandey, V.C., Rai, R.N. International journal of experimental pathology. (1991) [Pubmed]
  10. Depression of chemiluminescence during dengue virus infection of mice: role of cytokines. Dhawan, R., Chaturvedi, U.C., Mashihi, K.N., Chaturvedi, P., Mukherjee, R. International journal of experimental pathology. (1993) [Pubmed]
  11. Effect of dengue virus-induced cytotoxin on capillary permeability. Dhawan, R., Khanna, M., Chaturvedi, U.C., Mathur, A. Journal of experimental pathology (Oxford, England) (1990) [Pubmed]
  12. Characterization of the cytotoxin produced by macrophages in response to dengue virus-induced cytotoxic factor. Gulati, L., Chaturvedi, U.C., Mathur, A. British journal of experimental pathology. (1983) [Pubmed]
  13. Production of dengue virus-induced macrophage cytotoxin in vivo. Gulati, L., Chaturvedi, U.C., Mathur, A. British journal of experimental pathology. (1986) [Pubmed]
  14. Plasma membrane-acting drugs inhibit the effect of dengue virus-induced cytotoxic factor. Gulati, L., Chaturvedi, U.C., Mathur, A. Ann. Immunol. (Paris) (1983) [Pubmed]
  15. Dengue virus-induced cytotoxin releases nitrite by spleen cells. Mukerjee, R., Misra, A., Chaturvedi, U.C. International journal of experimental pathology. (1996) [Pubmed]
  16. Release of reactive oxygen intermediates by dengue virus-induced macrophage cytotoxin. Misra, A., Mukerjee, R., Chaturvedi, U.C. International journal of experimental pathology. (1996) [Pubmed]
  17. Monoclonal antibodies to conformational epitopes of the surface glycoprotein of caprine arthritis-encephalitis virus: potential application to competitive-inhibition enzyme-linked immunosorbent assay for detecting antibodies in goat sera. Ozyörük, F., Cheevers, W.P., Hullinger, G.A., McGuire, T.C., Hutton, M., Knowles, D.P. Clin. Diagn. Lab. Immunol. (2001) [Pubmed]
  18. Flow cytometric analysis of T4:T8 splenic cell during dengue virus infection of mice. Dhawan, R., Mukerjee, R., Chaturvedi, U.C., Khare, S.D. Indian J. Exp. Biol. (1995) [Pubmed]
 
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