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Gene Review:

Nphs1 - nephrosis 1, nephrin

Mus musculus

Synonyms: Nephrin, NephrinB, Nphn, Renal glomerulus-specific cell adhesion receptor, nephrin

Ihalmo, P. et al., Rantanen, M. et al., Moeller, M.J. et al.

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High impact information on Nphs1

Nephrin, encoded by Nphs1, is a structural protein of interpodocyte filtration slits crucial for formation of primary urine [1].
Evaluation of a new tool for exploring podocyte biology: mouse Nphs1 5' flanking region drives LacZ expression in podocytes [2].
Further evidence of the antisense transcript (Nphs1as) was obtained by searching for Nphs1-like expressed sequence tags [3].

Biological context of Nphs1

Nphs1as is a continuous, polyadenylated mRNA that spans Nphs1 exons from 7 to 12 in the reverse orientation [3].

Analytical, diagnostic and therapeutic context of Nphs1

Molecular cloning and characterization of an endogenous antisense transcript of Nphs1 [3].

References

Nephrin TRAP mice lack slit diaphragms and show fibrotic glomeruli and cystic tubular lesions. Rantanen, M., Palmén, T., Pätäri, A., Ahola, H., Lehtonen, S., Aström, E., Floss, T., Vauti, F., Wurst, W., Ruiz, P., Kerjaschki, D., Holthöfer, H. J. Am. Soc. Nephrol. (2002) [Pubmed]
Evaluation of a new tool for exploring podocyte biology: mouse Nphs1 5' flanking region drives LacZ expression in podocytes. Moeller, M.J., Kovari, I.A., Holzman, L.B. J. Am. Soc. Nephrol. (2000) [Pubmed]
Molecular cloning and characterization of an endogenous antisense transcript of Nphs1. Ihalmo, P., Rinta-Valkama, J., Mai, P., Aström, E., Palmén, T., Pham, T.T., Floss, T., Holthöfer, H. Genomics (2004) [Pubmed]

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