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Gene Review

KLHL24  -  kelch-like family member 24

Homo sapiens

Synonyms: DRE1, FLJ20059, KRIP6, Kainate receptor-interacting protein for GluR6, Kelch-like protein 24, ...
 
 
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Disease relevance of KLHL24

  • We have identified and analyzed a 45-nucleotide sequence (downstream regulatory element 1 [DRE 1]) at the boundary of the R/U5 region of the long terminal repeat which is required for HTLV-I basal transcription [1].
  • A stratification by results of the DRE (1 = normal, 2 = benign prostatic hyperplasia, 3 = prostate cancer suspected) yielded the following values: DRE 1: 2.40 versus 2.47; DRE 2: 2.99 versus 2.75; DRE 3: 3.64 versus 3.81; the difference was not significant for all three groups [2].
 

High impact information on KLHL24

  • On the basis of the molecular weight, DNA-binding characteristics, and in vivo transactivation activity, we suggest that the previously identified DRE 1-binding protein, p37, is YB-1 [3].
  • We previously identified and analyzed a 45-nucleotide sequence (downstream regulatory element 1 [DRE 1]), +195 to +240, at the boundary of the R/U5 region of the long terminal repeat which is required for HTLV-I basal transcription [3].
  • DRE 1 did not affect the level of Tax1 transactivation [1].
  • Following renaturation of the proteins isolated from an SDS-containing gel, p37, but not the other protein fractions, was able to specifically bind to DRE 1 [1].

References

  1. Sequences downstream of the RNA initiation site regulate human T-cell lymphotropic virus type I basal gene expression. Kashanchi, F., Duvall, J.F., Lindholm, P.F., Radonovich, M.F., Brady, J.N. J. Virol. (1993) [Pubmed]
  2. Variability of repeated serum prostate-specific antigen (PSA) measurements within less than 90 days in a well-defined patient population. Roehrborn, C.G., Pickens, G.J., Carmody, T. Urology (1996) [Pubmed]
  3. Involvement of transcription factor YB-1 in human T-cell lymphotropic virus type I basal gene expression. Kashanchi, F., Duvall, J.F., Dittmer, J., Mireskandari, A., Reid, R.L., Gitlin, S.D., Brady, J.N. J. Virol. (1994) [Pubmed]
 
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