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PIGG  -  phosphatidylinositol glycan anchor...

Homo sapiens

Synonyms: FLJ20265, GPI ethanolamine phosphate transferase 2, GPI7, GPI7 homolog, LAS21, ...
 
 
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High impact information on PIGG

  • We knocked down hGPI7 by RNA interference and found that H7 accumulated with little production of H8 [1].
  • Yeast GPI7 is involved in the transfer of EtNP to the second mannose, but the corresponding mammalian enzyme has not yet been clarified [1].
  • GPI7 is not essential, but its deletion renders cells hypersensitive to Calcofluor White, indicating cell wall fragility [2].
  • The bulk of Gpi7p is located at the plasma membrane, but a small amount is found in the endoplasmic reticulum [2].
  • Deletion of GPI7, a yeast gene required for addition of a side chain to the glycosylphosphatidylinositol (GPI) core structure, affects GPI protein transport, remodeling, and cell wall integrity [2].

References

  1. GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol. Shishioh, N., Hong, Y., Ohishi, K., Ashida, H., Maeda, Y., Kinoshita, T. J. Biol. Chem. (2005) [Pubmed]
  2. Deletion of GPI7, a yeast gene required for addition of a side chain to the glycosylphosphatidylinositol (GPI) core structure, affects GPI protein transport, remodeling, and cell wall integrity. Benachour, A., Sipos, G., Flury, I., Reggiori, F., Canivenc-Gansel, E., Vionnet, C., Conzelmann, A., Benghezal, M. J. Biol. Chem. (1999) [Pubmed]
 
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