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SEMA4C  -  sema domain, immunoglobulin domain (Ig),...

Homo sapiens

Synonyms: KIAA1739, M-SEMA-F, SEMACL1, SEMAF, SEMAI, ...
 
 
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Psychiatry related information on SEMA4C

  • The Semai have traditionally been relatively sexually egalitarian, and sex bias in care has not occurred [1].
 

High impact information on SEMA4C

  • 1. No disease-associated mutations were detected in the candidate genes SEMA4C, CNGA3 or HNK1ST from within the region [2].
  • The genetic structure of the total Semai population through time thus comprises a mosaic of shifiting allele frequencies in a series of semi-isolated local populations [3].
  • In addition, the individuals comprising Semai fission groups are kinsmen which implies that the number of independent genomes represented is markedly less than the number of individual migrants (the lineal effect) [4].
  • Blood samples, demographic and cultural data were collected from seven settlements of Semai Senoi, a swidden farming ethnic group of Malaysia. Three genetic loci (ABO blood group, hereditary ovalcytosis, and hemoglobin) were analyzed in a total sample of 546 individuals [3].
  • The Semai are characterized by high prevalences of ahaptoglobinemia and G6PD deficiency, high frequencies of HP*1, HB*E, RH*R1, ACP*C, GLO1*1, PGM1*2+, and GC*1F and corresponding low frequencies of ABO*A, HbCoSp, HB*B0, TF*D, CHI, and GC*2 [5].
 

Biological context of SEMA4C

  • Changing sex ratio of mortality in the Semai Senoi, 1969-1987 [1].
  • However, similar to genetic drift, KSM has its greatest effect in smaller populations and is most apparent in low-density fission-fusion societies such as the Yanomamo of South America and the Semai of Malaysia, and less salient in higher density, low-mobility populations such as those of the New Guinea Highlands [6].
 

Associations of SEMA4C with chemical compounds

  • Population genetic study among the Orange Asli (Semai Senoi) of Malaysia: Malayan aborigines [5].
 

Other interactions of SEMA4C

  • Adenosine deaminase polymorphism among the Semai, Temuan, Semelai, and Jakun groups of West Malaysian Orang Asli [7].
  • Only the common ADA1 and ADA2 alleles were found, with the frequencies of the latter being 0.025, 0.103, 0.115 and 0.028 in the Semai, Semelai, Temuan, and Jakun groups, respectively [7].

References

  1. Changing sex ratio of mortality in the Semai Senoi, 1969-1987. Fix, A.G. Hum. Biol. (1991) [Pubmed]
  2. A novel locus (RP33) for autosomal dominant retinitis pigmentosa mapping to chromosomal region 2cen-q12.1. Zhao, C., Lu, S., Zhou, X., Zhang, X., Zhao, K., Larsson, C. Hum. Genet. (2006) [Pubmed]
  3. Genetic microdifferentiation in the Semai Senoi of Malaysia. Fix, A.G., Lie-injo, L.E. Am. J. Phys. Anthropol. (1975) [Pubmed]
  4. Fission-fusion and lineal effect: aspects of the population structure of the Semai Senoi of Malaysia. Fix, A.G. Am. J. Phys. Anthropol. (1975) [Pubmed]
  5. Population genetic study among the Orange Asli (Semai Senoi) of Malaysia: Malayan aborigines. Saha, N., Mak, J.W., Tay, J.S., Liu, Y., Tan, J.A., Low, P.S., Singh, M. Hum. Biol. (1995) [Pubmed]
  6. Kin-structured migration: causes and consequences. Fix, A.G. Am. J. Hum. Biol. (2004) [Pubmed]
  7. Adenosine deaminase polymorphism among the Semai, Temuan, Semelai, and Jakun groups of West Malaysian Orang Asli. Welch, Q.B., Shu, L.C., Thangavelu, S., Lie-Injo, E.L. Hum. Hered. (1978) [Pubmed]
 
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