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RHBDL2  -  rhomboid, veinlet-like 2 (Drosophila)

Homo sapiens

Synonyms: FLJ20435, RRP2, Rhomboid-like protein 2, Rhomboid-related protein 2
 
 
 
 
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High impact information on RHBDL2

  • However, the membrane domains of several mammalian EGF-family proteins were not cleaved by RHBDL2, suggesting that the endogenous targets of the human protease are not EGF-related factors [1].
  • We demonstrate that the amino acid sequence at the luminal face of the membrane domain of a substrate protein determines whether it is cleaved by RHBDL2 [1].

References

  1. Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2. Pascall, J.C., Brown, K.D. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
 
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