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Gene Review

slit1a  -  slit homolog 1a (Drosophila)

Danio rerio

Synonyms: SO:0000704
 
 
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High impact information on slit1a

  • These glial ;bridges' form in regions devoid of the guidance molecules slit2 and slit3, although a subset of these glial cells express slit1a [1].
  • Whereas slit1a is expressed broadly in the central nervous system (CNS) and in the somites, pectoral fin buds, tail bud, and caudal fin folds, slit1b is expressed in the olfactory system throughout embryonic and larval development, and in the retina during larval stages [2].
  • Their expression patterns, particularly that of slit1a, suggest that Slit proteins may have roles in tissue morphogenesis in addition to their established roles in axon guidance and cell migration [2].
 

Anatomical context of slit1a

  • Both predicted proteins contain the conserved motifs that characterize other vertebrate Slits. slit1a and slit1b are both expressed in the midline, hypochord, telencephalon, and hindbrain [2].
 

Other interactions of slit1a

References

  1. Hedgehog regulated Slit expression determines commissure and glial cell position in the zebrafish forebrain. Barresi, M.J., Hutson, L.D., Chien, C.B., Karlstrom, R.O. Development (2005) [Pubmed]
  2. Two divergent slit1 genes in zebrafish. Hutson, L.D., Jurynec, M.J., Yeo, S.Y., Okamoto, H., Chien, C.B. Dev. Dyn. (2003) [Pubmed]
 
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