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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Lgals8  -  lectin, galactose binding, soluble 8

Mus musculus

Synonyms: 1200015E08Rik, AI326142, D13Ertd524e, Gal-8, Galectin-8, ...
 
 
 
 
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High impact information on Lgals8

  • After screening 3 x 10(6) clones from 3 different cDNA libraries, 15 tumor antigens were identified, including cytokeratin 2-8, glutamyl-prolyl-tRNA synthetase, complement C3, galectin 8, and serine/threonine-rich protein kinase 1 [1].
  • Inhibition of PI3K activity induced by wortmannin partially inhibits cell adhesion and spreading while largely inhibiting microspike formation in cells adherent to galectin-8 [2].
  • The above results suggest that galectin-8 is an extracellular matrix protein that triggers a unique repertoire of integrin-mediated signals, which leads to a distinctive cytoskeletal organization and microspike formation [2].
 

Analytical, diagnostic and therapeutic context of Lgals8

  • Ligation of integrins by galectin-8 triggers a distinct pattern of cytoskeletal organization, including formation of F-actin-containing microspikes [2].

References

  1. The tumor antigen repertoire identified in tumor-bearing Neu transgenic mice predicts human tumor antigens. Lu, H., Knutson, K.L., Gad, E., Disis, M.L. Cancer Res. (2006) [Pubmed]
  2. Sustained induction of ERK, protein kinase B, and p70 S6 kinase regulates cell spreading and formation of F-actin microspikes upon ligation of integrins by galectin-8, a mammalian lectin. Levy, Y., Ronen, D., Bershadsky, A.D., Zick, Y. J. Biol. Chem. (2003) [Pubmed]
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