Gene Review:
CPXM1 - carboxypeptidase X (M14 family), member 1
Homo sapiens
Synonyms:
CPX-1, CPX1, CPXM, Metallocarboxypeptidase CPX-1, UNQ3015/PRO9782
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Disease relevance of CPXM1
- Furthermore, CPX-1 expressed in either the baculovirus system or the mouse AtT-20 cell line does not cleave standard CP substrates [1].
High impact information on CPXM1
- In situ hybridization of CPX-1 mRNA in embryonic and fetal mouse tissue showed expression throughout the head and thorax, with abundance in primordial cartilage and skeletal structures [1].
- Northern blot analysis showed the highest levels of CPX-1 mRNA in testis and spleen and lower levels in salivary gland, brain, heart, lung, and kidney [1].
- In the head, high levels of CPX-1 mRNA were associated with the nasal mesenchyme, primordial cartilage structures in the ear, and the meninges [1].
- Instead, CPX-1 may have a role in development, possibly mediating cell interactions via its discoidin domain [1].
- In the thorax, CPX-1 mRNA was expressed in multiple developing skeletal structures, including chondrocytes and perichondrial cells of the rib, vertebral, and long-bone primordia [1].
Biological context of CPXM1
- However, several active-site residues that are important for catalytic activity of other CPs are not conserved in CPX-1 [1].
Other interactions of CPXM1
- Identification of mouse CPX-1, a novel member of the metallocarboxypeptidase gene family with highest similarity to CPX-2 [1].
References
- Identification of mouse CPX-1, a novel member of the metallocarboxypeptidase gene family with highest similarity to CPX-2. Lei, Y., Xin, X., Morgan, D., Pintar, J.E., Fricker, L.D. DNA Cell Biol. (1999) [Pubmed]
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