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Acot9  -  acyl-CoA thioesterase 9

Mus musculus

Synonyms: 0610041P13Rik, Acate2, Acyl coenzyme A thioester hydrolase 2, Acyl-CoA thioester hydrolase 9, Acyl-CoA thioesterase 9, ...
 
 
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Disease relevance of Acot9

  • U8 small nuclear RNA is a new, capped, 140 nucleotides long RNA species found in Novikoff hepatoma cells [1].
  • The rat U8 RNA was highly homologous (greater than 90%) to a recently characterized 5.4 S RNA from mouse cells infected with spleen focus-forming virus (Kato, N., and Harada, F. (1984) Biochim. Biophys. Acta, 782, 127-131) [1].
  • Although p48 is the most conserved subunit of mammalian DNA polymerase alpha-primase (pol-prim), the polypeptide is the major species-specific factor for mouse polyomavirus (PyV) DNA replication [2].
 

High impact information on Acot9

  • WD repeats of the p48 subunit of chicken chromatin assembly factor-1 required for in vitro interaction with chicken histone deacetylase-2 [3].
  • In addition to the U8 RNA, three other U small nuclear RNAs were found in anti-Sm antibody immunoprecipitates from labeled rat and HeLa cells [1].
  • More precisely, the nonconserved phenylalanine 262 of mouse p48 is crucial for this activity, and pol-prim with mutant p48, h-S262F, supports PyV DNA replication in vitro [2].
  • A basic helix-loop-helix protein, p48 of pancreas transcription factor 1 (PTF1), is essential for differentiation of the exocrine acinar cells [4].
  • Alignment of these three Xenopus U8 sequences with the previously described mammalian U8 homologues in mouse, rat and human has provided information about evolutionarily conserved sequence and structural elements in U8 RNA [5].
 

Anatomical context of Acot9

  • Fibroblasts and terminally differentiated myocytes of the rat heart display equally efficient GGR of 6-4PP but poor repair of CPD due to the absence of p48 expression [6].
 

Analytical, diagnostic and therapeutic context of Acot9

  • Sequence analysis of the coding regions of these two genes indicate that both differ at several positions from the previously characterized U8 RNA and that the two differ from each other [5].
  • Using cloning cylinders and subsequent limiting dilution techniques, we obtained two clones, MTE-1 and MTE-2 [7].

References

  1. Primary and secondary structure of U8 small nuclear RNA. Reddy, R., Henning, D., Busch, H. J. Biol. Chem. (1985) [Pubmed]
  2. Amino acids 257 to 288 of mouse p48 control the cooperation of polyomavirus large T antigen, replication protein A, and DNA polymerase alpha-primase to synthesize DNA in vitro. Kautz, A.R., Weisshart, K., Schneider, A., Grosse, F., Nasheuer, H.P. J. Virol. (2001) [Pubmed]
  3. WD repeats of the p48 subunit of chicken chromatin assembly factor-1 required for in vitro interaction with chicken histone deacetylase-2. Ahmad, A., Takami, Y., Nakayama, T. J. Biol. Chem. (1999) [Pubmed]
  4. p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos. Obata, J., Yano, M., Mimura, H., Goto, T., Nakayama, R., Mibu, Y., Oka, C., Kawaichi, M. Genes Cells (2001) [Pubmed]
  5. The U8 snoRNA gene family: identification and characterization of distinct, functional U8 genes in Xenopus. Peculis, B.A., DeGregorio, S., McDowell, K. Gene (2001) [Pubmed]
  6. Nucleotide excision repair in differentiated cells. van der Wees, C., Jansen, J., Vrieling, H., van der Laarse, A., Van Zeeland, A., Mullenders, L. Mutat. Res. (2007) [Pubmed]
  7. Establishment and characterization of mouse thymic epithelial cell lines. Naquet, P., Lepesant, H., Luxembourg, A., Brekelmans, P., Devaux, C., Pierres, M. Thymus (1989) [Pubmed]
 
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