High impact information on 1500003O03Rik

• However, unlike classical Rho GTPases, we recently found that Chp depends on palmitoylation, rather than prenylation, for association with cellular membranes [1].
• Because palmitoylation alone is typically not sufficient to promote membrane association, we evaluated the possibility that other carboxy-terminal residues facilitate Chp subcellular association with membranes [1].
• Multiple sequence elements facilitate Chp Rho GTPase subcellular location, membrane association, and transforming activity [1].
• We found that Chp membrane association and transforming activity was dependent on the integrity of a stretch of basic amino acids in the carboxy terminus of Chp and that the basic amino acids were not simply part of a palmitoyl acyltransferase recognition motif [1].
• The Chp system is also required for full virulence in a mouse model of acute pneumonia [2].

Biological context of 1500003O03Rik

• We show that the Chp chemosensory system controls twitching motility and type IV pili biogenesis through control of pili assembly and/or retraction as well as expression of the pilin subunit gene pilA [2].

Associations of 1500003O03Rik with chemical compounds

• Finally, we found that Chp membrane association was not disrupted by Rho guanine nucleotide dissociation inhibitory proteins, which are negative regulators of Cdc42 membrane association and biological activity [1].

References