Gene Review:
Tbk1 - TANK-binding kinase 1
Mus musculus
Synonyms:
1200008B05Rik, AI462036, AW048562, Serine/threonine-protein kinase TBK1, T2K
- Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection. Perry, A.K., Chow, E.K., Goodnough, J.B., Yeh, W.C., Cheng, G. J. Exp. Med. (2004)
- The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. Hemmi, H., Takeuchi, O., Sato, S., Yamamoto, M., Kaisho, T., Sanjo, H., Kawai, T., Hoshino, K., Takeda, K., Akira, S. J. Exp. Med. (2004)
- IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. McWhirter, S.M., Fitzgerald, K.A., Rosains, J., Rowe, D.C., Golenbock, D.T., Maniatis, T. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription. Bonnard, M., Mirtsos, C., Suzuki, S., Graham, K., Huang, J., Ng, M., Itié, A., Wakeham, A., Shahinian, A., Henzel, W.J., Elia, A.J., Shillinglaw, W., Mak, T.W., Cao, Z., Yeh, W.C. EMBO J. (2000)
- Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex. Youn, H.S., Lee, J.Y., Fitzgerald, K.A., Young, H.A., Akira, S., Hwang, D.H. J. Immunol. (2005)