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Trpm5  -  transient receptor potential cation...

Mus musculus

Synonyms: 9430099A16Rik, LTrpC-5, LTrpC5, Long transient receptor potential channel 5, Ltrpc5, ...
 
 
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High impact information on Trpm5

 

Biological context of Trpm5

  • Tssc4 and Mtr1 carried putative open reading frames but neither was imprinted [6].
  • A previous study reported that mice with an internal deletion of Trpm5, lacking exons 15-19 encoding transmembrane segments 1-5, showed no taste-mediated responses to bitter, sweet, and umami compounds [7].
 

Anatomical context of Trpm5

  • The duodenal gland cells that coexpress PLCbeta2 and Trpm5 morphologically resemble enteroendocrine cells [8].
  • Using transgenic mice expressing enhanced green fluorescent protein under the control of the Trpm5 promoter, we found colocalization of Trpm5 and alpha-gustducin in tufted cells at the surface epithelium of the colon, but these cells did not express T1r3 or PLCbeta2 [8].
 

Other interactions of Trpm5

  • In the duodenal glands, 43%, 33%, and 38% of Trpm5-expressing cells also express PLCbeta2, T1r3, or alpha-gustducin, respectively [8].
 

Analytical, diagnostic and therapeutic context of Trpm5

  • Imprinting analysis, using RT-PCR on RNA from reciprocal mouse crosses harboring a sequence polymorphism, revealed biallelic expression of Mtr1 transcripts at all stages and tissues examined [5].

References

  1. A transient receptor potential channel expressed in taste receptor cells. Pérez, C.A., Huang, L., Rong, M., Kozak, J.A., Preuss, A.K., Zhang, H., Max, M., Margolskee, R.F. Nat. Neurosci. (2002) [Pubmed]
  2. Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell differentiation and nuage/germinal granule formation in mice. Chuma, S., Hosokawa, M., Kitamura, K., Kasai, S., Fujioka, M., Hiyoshi, M., Takamune, K., Noce, T., Nakatsuji, N. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse. Paulsen, M., El-Maarri, O., Engemann, S., Strödicke, M., Franck, O., Davies, K., Reinhardt, R., Reik, W., Walter, J. Hum. Mol. Genet. (2000) [Pubmed]
  4. Mouse Tudor Repeat-1 (MTR-1) is a novel component of chromatoid bodies/nuages in male germ cells and forms a complex with snRNPs. Chuma, S., Hiyoshi, M., Yamamoto, A., Hosokawa, M., Takamune, K., Nakatsuji, N. Mech. Dev. (2003) [Pubmed]
  5. Mtr1, a novel biallelically expressed gene in the center of the mouse distal chromosome 7 imprinting cluster, is a member of the Trp gene family. Enklaar, T., Esswein, M., Oswald, M., Hilbert, K., Winterpacht, A., Higgins, M., Zabel, B., Prawitt, D. Genomics (2000) [Pubmed]
  6. Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and human. Yatsuki, H., Watanabe, H., Hattori, M., Joh, K., Soejima, H., Komoda, H., Xin, Z., Zhu, X., Higashimoto, K., Nishimura, M., Kuratomi, S., Sasaki, H., Sakaki, Y., Mukai, T. DNA Res. (2000) [Pubmed]
  7. Trpm5 null mice respond to bitter, sweet, and umami compounds. Damak, S., Rong, M., Yasumatsu, K., Kokrashvili, Z., Pérez, C.A., Shigemura, N., Yoshida, R., Mosinger, B., Glendinning, J.I., Ninomiya, Y., Margolskee, R.F. Chem. Senses (2006) [Pubmed]
  8. Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells. Bezen??on, C., le Coutre, J., Damak, S. Chem. Senses (2007) [Pubmed]
 
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