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PCBP4  -  poly(rC) binding protein 4

Homo sapiens

Synonyms: Alpha-CP4, CBP, LIP4, MCG10, Poly(rC)-binding protein 4
 
 
 
 
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Disease relevance of PCBP4

 

High impact information on PCBP4

 

Biological context of PCBP4

  • In addition, we found that MCG10 and MCG10as, through their KH domains, can bind poly(C) and that their RNA-binding activity is necessary for inducing apoptosis and cell cycle arrest [2].
  • Finally, induction of alpha CP-4 expression reduced cell growth, in agreement with its proposed role as a tumor suppressor, and suggesting an association of this RNA-binding protein with lung carcinogenesis [1].
  • Alpha CP-4, encoded by a putative tumor suppressor gene at 3p21, but not its alternative splice variant alpha CP-4a, is underexpressed in lung cancer [1].
 

Anatomical context of PCBP4

  • In NSCLC biopsies, an immunocytochemical analysis showed cytoplasmic expression of alpha CP-4 and alpha CP-4a in normal lung bronchiolar epithelium [1].

References

  1. Alpha CP-4, encoded by a putative tumor suppressor gene at 3p21, but not its alternative splice variant alpha CP-4a, is underexpressed in lung cancer. Pio, R., Zudaire, I., Pino, I., Castaño, Z., Zabalegui, N., Vicent, S., Garcia-Amigot, F., Odero, M.D., Lozano, M.D., Garcia-Foncillas, J., Calasanz, M.J., Montuenga, L.M. Cancer Res. (2004) [Pubmed]
  2. MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M. Zhu, J., Chen, X. Mol. Cell. Biol. (2000) [Pubmed]
 
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