Gene Review:
bcl2a - B-cell CLL/lymphoma 2a
Danio rerio
Synonyms:
SO:0000704
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Disease relevance of bcl2
- To test the ability of bcl-2 to block irradiation-induced apoptosis in malignant cells, we compared the responsiveness of Myc-induced leukemias with and without EGFP-bcl-2 expression in living transgenic zebrafish [1].
High impact information on bcl2
- Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish [1].
- Here we describe a transgenic zebrafish line in which T- and B-lymphoid cells express a fusion transgene that encodes the zebrafish bcl-2 protein fused to the enhanced green fluorescence protein (EGFP) [1].
- T-cell leukemias induced by the rag2-EGFP-Myc transgene were ablated by irradiation, whereas leukemias in double transgenic fish expressing both Myc and EGFP-bcl-2 were resistant to irradiation-induced apoptotic cell death [1].
- Targeting EGFP-bcl-2 to the developing thymocytes of transgenic fish resulted in a 2.5-fold increase in thymocyte numbers and a 1.8-fold increase in GFP-labeled B cells in the kidney marrow [1].
Associations of bcl2 with chemical compounds
- Fluorescent microscopic analysis of living rag2-EGFP-bcl-2 transgenic fish showed that their thymocytes were resistant to irradiation- and dexamethasone-induced apoptosis, when compared with control rag2-GFP transgenic zebrafish [1].
References
- Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish. Langenau, D.M., Jette, C., Berghmans, S., Palomero, T., Kanki, J.P., Kutok, J.L., Look, A.T. Blood (2005) [Pubmed]
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