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Gene Review

IL4  -  interleukin 4

Macaca mulatta

 
 
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Disease relevance of IL4

 

High impact information on IL4

  • Neuropathogenesis of lentiviral infection in macaques: roles of CXCR4 and CCR5 viruses and interleukin-4 in enhancing monocyte chemoattractant protein-1 production in macrophages [2].
  • SIV antibody titers and the affinity of these antibodies were higher in SIV-IL4-infected macaques than in SIV-IFN-infected animals, consistent with a stimulation of T helper cell type 2 immune responses by IL-4 [1].

References

  1. Replication, immunogenicity, and protective properties of live-attenuated simian immunodeficiency viruses expressing interleukin-4 or interferon-gamma. Stahl-Hennig, C., Gundlach, B.R., Dittmer, U., ten Haaft, P., Heeney, J., Zou, W., Emilie, D., Sopper, S., Uberla, K. Virology (2003) [Pubmed]
  2. Neuropathogenesis of lentiviral infection in macaques: roles of CXCR4 and CCR5 viruses and interleukin-4 in enhancing monocyte chemoattractant protein-1 production in macrophages. Hicks, A., Potula, R., Sui, Y.J., Villinger, F., Pinson, D., Adany, I., Li, Z., Long, C., Cheney, P., Marcario, J., Novembre, F., Mueller, N., Kumar, A., Major, E., Narayan, O., Buch, S. Am. J. Pathol. (2002) [Pubmed]
 
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