The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Isg20  -  interferon-stimulated protein

Mus musculus

Synonyms: 1600023I01Rik, 2010107M23Rik, 20kDa, DnaQL, DnaQl, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Isg20

 

High impact information on Isg20

 

Biological context of Isg20

 

Anatomical context of Isg20

 

Physical interactions of Isg20

 

Regulatory relationships of Isg20

  • Interferon stimulated gene 15 conjugates to endometrial cytosolic proteins and is expressed at the uterine-placental interface throughout pregnancy in sheep [22].
 

Other interactions of Isg20

 

Analytical, diagnostic and therapeutic context of Isg20

  • Electrophoretic mobility shift assay performed with the virus-inducible fragments containing these motifs indicated that the binding activity that we have denoted as virus-induced factor (Génin, P., Bragança, J., Darracq, N., Doly, J., and Civas, A. (1995) Nucleic Acids Res. 23, 5055-5063) is different from interferon-stimulated gene factor 3 [28].
  • As soon as 15min post oral administration with BmrhGM-CSF labeled with (125)I, an approximately 20kDa protein fragment was detected within mice blood by SDS-PAGE followed by autoradiography [29].

References

  1. Differentiation-dependent activation of interferon-stimulated gene factors and transcription factor NF-kappa B in mouse embryonal carcinoma cells. Kalvakolanu, D.V., Sen, G.C. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. ISG15, an interferon-stimulated ubiquitin-like protein, is not essential for STAT1 signaling and responses against vesicular stomatitis and lymphocytic choriomeningitis virus. Osiak, A., Utermöhlen, O., Niendorf, S., Horak, I., Knobeloch, K.P. Mol. Cell. Biol. (2005) [Pubmed]
  3. In vivo footprinting of the mouse inducible nitric oxide synthase gene: inducible protein occupation of numerous sites including Oct and NF-IL6. Goldring, C.E., Reveneau, S., Algarté, M., Jeannin, J.F. Nucleic Acids Res. (1996) [Pubmed]
  4. Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo. Lenschow, D.J., Giannakopoulos, N.V., Gunn, L.J., Johnston, C., O'Guin, A.K., Schmidt, R.E., Levine, B., Virgin, H.W. J. Virol. (2005) [Pubmed]
  5. Vesicular stomatitis virus infection induces a nuclear DNA-binding factor specific for the interferon-stimulated response element. Bovolenta, C., Lou, J., Kanno, Y., Park, B.K., Thornton, A.M., Coligan, J.E., Schubert, M., Ozato, K. J. Virol. (1995) [Pubmed]
  6. A partial genomic DNA clone for the alpha subunit of the mouse complement receptor type 3 and cellular adhesion molecule Mac-1. Sastre, L., Roman, J.M., Teplow, D.B., Dreyer, W.J., Gee, C.E., Larson, R.S., Roberts, T.M., Springer, T.A. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  7. Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway. You, M., Yu, D.H., Feng, G.S. Mol. Cell. Biol. (1999) [Pubmed]
  8. Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1. Weaver, B.K., Kumar, K.P., Reich, N.C. Mol. Cell. Biol. (1998) [Pubmed]
  9. The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells. Briggs, R.C., Briggs, J.A., Ozer, J., Sealy, L., Dworkin, L.L., Kingsmore, S.F., Seldin, M.F., Kaur, G.P., Athwal, R.S., Dessypris, E.N. Blood (1994) [Pubmed]
  10. Characterization of promoter elements of an interferon-inducible Ly-6E/A differentiation antigen, which is expressed on activated T cells and hematopoietic stem cells. Khan, K.D., Lindwall, G., Maher, S.E., Bothwell, A.L. Mol. Cell. Biol. (1990) [Pubmed]
  11. Cells previously desensitized to type 1 interferons display different mechanisms of activation of stat-dependent gene expression from naïve cells. Sakamoto, S., Qin, J., Navarro, A., Gamero, A., Potla, R., Yi, T., Zhu, W., Baker, D.P., Feldman, G., Larner, A.C. J. Biol. Chem. (2004) [Pubmed]
  12. Virus infection and interferon can activate gene expression through a single synthetic element, but endogenous genes show distinct regulation. Raj, N.B., Engelhardt, J., Au, W.C., Levy, D.E., Pitha, P.M. J. Biol. Chem. (1989) [Pubmed]
  13. Characterization and expression analyses of the mouse Wiskott-Aldrich syndrome protein (WASP) family member Wave1/Scar. Benachenhou, N., Massy, I., Vacher, J. Gene (2002) [Pubmed]
  14. ISG15, not just another ubiquitin-like protein. Kim, K.I., Zhang, D.E. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  15. Molecular determinants of Ebola virus virulence in mice. Ebihara, H., Takada, A., Kobasa, D., Jones, S., Neumann, G., Theriault, S., Bray, M., Feldmann, H., Kawaoka, Y. PLoS Pathog. (2006) [Pubmed]
  16. A PI-3 kinase-dependent, Stat1-independent signaling pathway regulates interferon-stimulated monocyte adhesion. Navarro, A., Anand-Apte, B., Tanabe, Y., Feldman, G., Larner, A.C. J. Leukoc. Biol. (2003) [Pubmed]
  17. Murine gamma interferon fails to inhibit Toxoplasma gondii growth in murine fibroblasts. Schwartzman, J.D., Gonias, S.L., Pfefferkorn, E.R. Infect. Immun. (1990) [Pubmed]
  18. Basis for dosing time-dependent changes in the antiviral activity of interferon-alpha in mice. Ohdo, S., Wang, D.S., Koyanagi, S., Takane, H., Inoue, K., Aramaki, H., Yukawa, E., Higuchi, S. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  19. Self-generating density gradients of Percoll provide a simple and rapid method that consistently enriches natural killer cells. Ravnik, S.E., Gage, S., Pollack, S.B. J. Immunol. Methods (1988) [Pubmed]
  20. Identification and partial characterization of FRAG-6, a novel interferon-stimulated gene that is expressed in an IRF-1-INDEPENDENT manner. Silva, A.M., Bottrel, R.L., Reis, L.F. Cytokine (1999) [Pubmed]
  21. Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE). Matsuyama, T., Grossman, A., Mittrücker, H.W., Siderovski, D.P., Kiefer, F., Kawakami, T., Richardson, C.D., Taniguchi, T., Yoshinaga, S.K., Mak, T.W. Nucleic Acids Res. (1995) [Pubmed]
  22. Interferon stimulated gene 15 conjugates to endometrial cytosolic proteins and is expressed at the uterine-placental interface throughout pregnancy in sheep. Joyce, M.M., White, F.J., Burghardt, R.C., Muñiz, J.J., Spencer, T.E., Bazer, F.W., Johnson, G.A. Endocrinology (2005) [Pubmed]
  23. Structure and expression of the murine Sp100 nuclear dot gene. Weichenhan, D., Kunze, B., Zacker, S., Traut, W., Winking, H. Genomics (1997) [Pubmed]
  24. Cells resistant to interferon-beta respond to interferon-gamma via the Stat1-IRF-1 pathway. Coccia, E.M., Marziali, G., Stellacci, E., Perrotti, E., Ilari, R., Orsatti, R., Battistini, A. Virology (1995) [Pubmed]
  25. The immune response modifier imiquimod requires STAT-1 for induction of interferon, interferon-stimulated genes, and interleukin-6. Bottrel, R.L., Yang, Y.L., Levy, D.E., Tomai, M., Reis, L.F. Antimicrob. Agents Chemother. (1999) [Pubmed]
  26. Involvement of the interferon-regulated antiviral proteins PKR and RNase L in reovirus-induced shutoff of cellular translation. Smith, J.A., Schmechel, S.C., Williams, B.R., Silverman, R.H., Schiff, L.A. J. Virol. (2005) [Pubmed]
  27. RNase-L-dependent destabilization of interferon-induced mRNAs. A role for the 2-5A system in attenuation of the interferon response. Li, X.L., Blackford, J.A., Judge, C.S., Liu, M., Xiao, W., Kalvakolanu, D.V., Hassel, B.A. J. Biol. Chem. (2000) [Pubmed]
  28. Synergism between multiple virus-induced factor-binding elements involved in the differential expression of interferon A genes. Bragança, J., Génin, P., Bandu, M.T., Darracq, N., Vignal, M., Cassé, C., Doly, J., Civas, A. J. Biol. Chem. (1997) [Pubmed]
  29. Can 29kDa rhGM-CSF expressed by silkworm pupae bioreactor bring into effect as active cytokine through orally administration? Zhang, Y., Chen, J., Lv, Z., Nie, Z., Zhang, X., Wu, X. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (2006) [Pubmed]
 
WikiGenes - Universities