The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

KIDINS220  -  kinase D-interacting substrate, 220kDa

Homo sapiens

Synonyms: ARMS, Ankyrin repeat-rich membrane-spanning protein, KIAA1250, Kinase D-interacting substrate of 220 kDa
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on KIDINS220

  • In addition, Kidins220/ARMS and kinesin-1 were shown to colocalize in nerve growth factor (NGF)-differentiated PC12 cells [1].
  • We identified kinesin light chain 1 (KLC1) as a binding partner for Kidins220/ARMS by a yeast two-hybrid screen [1].
  • The interaction between Kidins220/ARMS and the kinesin-1 motor complex was confirmed by glutathione S-transferase-pull-down and coimmunoprecipitation experiments [1].
  • Kidins220/ARMS Is Transported by a Kinesin-1-based Mechanism Likely to be Involved in Neuronal Differentiation [1].
  • Moreover, a peptide within the Kidins220 sequence, containing serine 919 in a consensus motif for PKD-specific phosphorylation, behaved as the best peptide substrate to date [2].
 

Biological context of KIDINS220

  • Furthermore, by generating an antibody recognizing Kidins220 phosphorylated on serine 919, we show that phorbol ester treatment causes the specific phosphorylation of this residue in PC12 cells in vivo [2].
  • Kidins220 contains 11 ankyrin repeats and four transmembrane domains within the N-terminal region [2].
  • Animal KAP NTPases, including Kidins220/ARMS, are likely to function as NTP-dependent regulators of the assembly of membrane-associated signaling complexes involved in neurite growth and development [3].
 

Anatomical context of KIDINS220

  • The neuronal protein Kidins220 localizes in a raft compartment at the leading edge of motile immature dendritic cells [4].
  • We have shown that Kidins220 is an integral membrane protein selectively expressed in brain and neuroendocrine cells, where it concentrates at the tip of neurites [2].
 

Associations of KIDINS220 with chemical compounds

  • Disruption of rafts with methyl-beta-cyclodextrin induced rounding of the cells, inhibition of motility and lost of Kidins220 polarization [4].
 

Other interactions of KIDINS220

References

  1. Kidins220/ARMS Is Transported by a Kinesin-1-based Mechanism Likely to be Involved in Neuronal Differentiation. Bracale, A., Cesca, F., Neubrand, V.E., Newsome, T.P., Way, M., Schiavo, G. Mol. Biol. Cell (2007) [Pubmed]
  2. Identification and cloning of Kidins220, a novel neuronal substrate of protein kinase D. Iglesias, T., Cabrera-Poch, N., Mitchell, M.P., Naven, T.J., Rozengurt, E., Schiavo, G. J. Biol. Chem. (2000) [Pubmed]
  3. A novel family of P-loop NTPases with an unusual phyletic distribution and transmembrane segments inserted within the NTPase domain. Aravind, L., Iyer, L.M., Leipe, D.D., Koonin, E.V. Genome Biol. (2004) [Pubmed]
  4. The neuronal protein Kidins220 localizes in a raft compartment at the leading edge of motile immature dendritic cells. Riol-Blanco, L., Iglesias, T., Sánchez-Sánchez, N., de la Rosa, G., Sánchez-Ruiloba, L., Cabrera-Poch, N., Torres, A., Longo, I., García-Bordas, J., Longo, N., Tejedor, A., Sánchez-Mateos, P., Rodríguez-Fernández, J.L. Eur. J. Immunol. (2004) [Pubmed]
 
WikiGenes - Universities