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Gene Review

PCDH10  -  protocadherin 10

Homo sapiens

Synonyms: KIAA1400, OL-PCDH, PCDH19, Protocadherin-10
 
 
 
 
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Disease relevance of PCDH10

  • Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation [1].
 

High impact information on PCDH10

  • The transcriptional silencing of PCDH10 could be reversed by pharmacologic demethylation with 5-aza-2'-deoxycytidine or genetic demethylation with double knockout of DNMT1 and DNMT3B, indicating a direct epigenetic mechanism [1].
  • It resides at 4q28.3--a region with hemizygous deletion detected by array-CGH in NPC cell lines; however, PCDH10 itself is not located within the deletion [1].
  • Ectopic expression of PCDH10 strongly suppressed tumor cell growth, migration, invasion and colony formation [1].
  • PCDH10 is broadly expressed in all normal adult and fetal tissues including the epithelia, though at different levels [1].
  • As tumor-specific promoter methylation is a marker for tumor suppressor genes (TSG), we searched for epigenetically inactivated TSGs using methylation-subtraction combined with pharmacologic demethylation, and identified the PCDH10 CpG island as a methylated sequence in nasopharyngeal carcinoma (NPC) [1].

References

  1. Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation. Ying, J., Li, H., Seng, T.J., Langford, C., Srivastava, G., Tsao, S.W., Putti, T., Murray, P., Chan, A.T., Tao, Q. Oncogene (2006) [Pubmed]
 
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