Gene Review:
ZNF492 - zinc finger protein 492
Homo sapiens
Synonyms:
KIAA1473, ZNF115, Zinc finger protein 115, Zinc finger protein 492
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High impact information on ZNF492
- CONCLUSIONS: We have identified ZNF492, a KRAB-zinc finger protein, by its interaction with immobilized RPE65 promoter DNA sequence [1].
- RESULTS: We identified a D407 nuclear protein binding to biotinylated-DNA/streptavidin beads as the product of clone KIAA1473 encoding a protein named ZNF492 [1].
- In ZNF492, absence of KRAB-A might reduce or prevent co-repressor binding to account for the modest upregulation of Rpe65 gene expression [1].
- ZNF492 has an open reading frame of 531 amino acids with a truncated N-terminus and lacks the usual Krüppel-associated box-A (KRAB-A) while KRAB-B remains intact and has 12 C2H2 zinc-fingers in tandem arrangement [1].
References
- Identification of a KRAB-zinc finger protein binding to the Rpe65 gene promoter. Lu, Z., Poliakov, E., Redmond, T.M. Curr. Eye Res. (2006) [Pubmed]
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