Gene Review:
ARHGAP23 - Rho GTPase activating protein 23
Homo sapiens
Synonyms:
KIAA1501, Rho GTPase-activating protein 23, Rho-type GTPase-activating protein 23
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Disease relevance of ARHGAP23
- ARHGAP23 mRNA was expressed in placenta, prostate, hippocampus, brain medulla as well as in brain tumor, salivary gland tumor, head and neck tumor [1].
High impact information on ARHGAP23
- Human ARHGAP23, ARHGAP21 and Xenopus rGAP shared the common domain structure consisting of PDZ, Pleckstrin homology (PH), and RhoGAP domains [1].
- ARHGAP23 gene encoded 1491-aa isoform 1 (without exon 23) and 1144-aa isoform 2 (with exon 23) due to alternative splicing [1].
- Here, we identified and characterized the ARHGAP23 gene by using bioinformatics [1].
- Complete coding sequence of human ARHGAP23 cDNA was determined by assembling BM806021 EST, BQ718622 EST, KIAA1501 partial cDNA, and AC115090.8 genome sequence corresponding to exons 7 and 25 [1].
- Mouse 4933428G20 (NM_021493.1) was a 5'-truncated partial cDNA derived from Arhgap23 gene at mouse chromosome 11D [1].
References
- Identification and characterization of human ARHGAP23 gene in silico. Katoh, M., Katoh, M. Int. J. Oncol. (2004) [Pubmed]
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