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Gene Review

SPTBN4  -  spectrin, beta, non-erythrocytic 4

Homo sapiens

Synonyms: Beta-IV spectrin, KIAA1642, QV, SPNB4, SPTBN3, ...
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High impact information on SPTBN4


Biological context of SPTBN4


Anatomical context of SPTBN4


Other interactions of SPTBN4

  • NF-Fc significantly inhibited nodal clustering of Na(+) channels, ankyrin(G), and betaIV spectrin, and modestly reduced Caspr clustering at paranodal junctions; it did not significantly affect lengths or numbers of myelin-positive segments, axon initial segments, or accumulations of phosphorylated-ERM proteins in Schwann cell nodal microvilli [5].


  1. [Beta]IV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier. Komada, M., Soriano, P. J. Cell Biol. (2002) [Pubmed]
  2. betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous system. Berghs, S., Aggujaro, D., Dirkx, R., Maksimova, E., Stabach, P., Hermel, J.M., Zhang, J.P., Philbrick, W., Slepnev, V., Ort, T., Solimena, M. J. Cell Biol. (2000) [Pubmed]
  3. Lateral membrane biogenesis in human bronchial epithelial cells requires 190-kDa ankyrin-G. Kizhatil, K., Bennett, V. J. Biol. Chem. (2004) [Pubmed]
  4. Autoimmunity to beta IV spectrin in paraneoplastic lower motor neuron syndrome. Berghs, S., Ferracci, F., Maksimova, E., Gleason, S., Leszczynski, N., Butler, M., De Camilli, P., Solimena, M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  5. Neurofascin interactions play a critical role in clustering sodium channels, ankyrin(G) and betaIV spectrin at peripheral nodes of Ranvier. Koticha, D., Maurel, P., Zanazzi, G., Kane-Goldsmith, N., Basak, S., Babiarz, J., Salzer, J., Grumet, M. Dev. Biol. (2006) [Pubmed]
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