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Gene Review:

Slc15a2 - solute carrier family 15 (H+/peptide...

Mus musculus

Synonyms: 8430408C16Rik, C78862, Kidney H(+)/peptide cotransporter, Oligopeptide transporter, kidney isoform, Pept2, ...

Frey, I.M. et al., Ocheltree, S.M. et al., Ocheltree, S.M. et al., Rubio-Aliaga, I. et al., Rubio-Aliaga, I. et al.

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High impact information on Slc15a2

The Pept2(-/-) mice showed no obvious phenotypic abnormalities but also no adaptive upregulation in the expression level of related genes in the kidney [1].
Role and relevance of peptide transporter 2 (PEPT2) in the kidney and choroid plexus: in vivo studies with glycylsarcosine in wild-type and PEPT2 knockout mice [2].
By radiation mapping analysis the Pept2 gene was mapped on central mouse chromosome 16 [3].
The murine Pept2 gene was cloned from a 129/SvevTACfBr genomic library [3].
When fed diets with different protein contents, Pept2 (-/-) mice adapted food intake to dietary protein content with higher consumption rates on low protein and reduced food intake rates on the high protein diet [4].

Anatomical context of Slc15a2

The choroid plexus uptake of [(3)H]cefadroxil was studied in peptide transporter 2 (PEPT2) wild-type and null mice as a function of temperature, transport inhibitors, pH, and saturability [5].

References

Targeted disruption of the peptide transporter Pept2 gene in mice defines its physiological role in the kidney. Rubio-Aliaga, I., Frey, I., Boll, M., Groneberg, D.A., Eichinger, H.M., Balling, R., Daniel, H. Mol. Cell. Biol. (2003) [Pubmed]
Role and relevance of peptide transporter 2 (PEPT2) in the kidney and choroid plexus: in vivo studies with glycylsarcosine in wild-type and PEPT2 knockout mice. Ocheltree, S.M., Shen, H., Hu, Y., Keep, R.F., Smith, D.E. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
Cloning and characterization of the gene encoding the mouse peptide transporter PEPT2. Rubio-Aliaga, I., Boll, M., Daniel, H. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
Phenotype analysis of mice deficient in the peptide transporter PEPT2 in response to alterations in dietary protein intake. Frey, I.M., Rubio-Aliaga, I., Klempt, M., Wolf, E., Daniel, H. Pflugers Arch. (2006) [Pubmed]
Mechanisms of cefadroxil uptake in the choroid plexus: studies in wild-type and PEPT2 knockout mice. Ocheltree, S.M., Shen, H., Hu, Y., Xiang, J., Keep, R.F., Smith, D.E. J. Pharmacol. Exp. Ther. (2004) [Pubmed]

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AgaP_AGAP012154	Anopheles gambiae str. PEST
pept-3	Caenorhabditis elegans
SLC15A2	Canis lupus familiaris
slc15a2	Danio rerio
SLC15A2	Gallus gallus
SLC15A2	Homo sapiens
SLC15A2	Macaca mulatta
Os03g0235700	Oryza sativa Japonica Group
SLC15A2	Pan troglodytes
Slc15a2	Rattus norvegicus
slc15a2	Xenopus (Silurana) tropicalis

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