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Rhbg  -  Rhesus blood group-associated B glycoprotein

Mus musculus

Synonyms: Ammonium transporter Rh type B, Rh family type B glycoprotein, Rh type B glycoprotein, Rhesus blood group family type B glycoprotein
 
 
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Disease relevance of Rhbg

  • Human RHBG resides at chromosome 1q21.3, which harbors candidate genes for medullary cystic kidney disease, whereas mouse Rhbg is syntenic on chromosome 3 [1].
  • Therefore, it has been proposed that rhesus type B glycoprotein (Rhbg), a member of the Mep/Amt/Rh NH(3) channel superfamily, may be involved in some forms of distal tubular acidosis and congenital hyperammonemia [2].
 

High impact information on Rhbg

  • In oocytes expressing Rhbg, net NH(4)(+) influx (estimated from NH(4)(+)-induced H(+) influx) as a function of external [NH(4)(+)] saturated at higher [NH(4)(+)] with a V(max) of approximately 30.8 and an apparent K(m) of 2.3 mM (R(2) = 0.99) [3].
  • Characteristics of renal Rhbg as an NH4(+) transporter [3].
  • Rhbg is expressed in basolateral membranes of intercalated cells of the kidney cortical collecting duct and some other cell types of the distal nephron and may function as NH(4)(+) transporters [3].
  • Recently, two non-erythroid Rh glycoproteins were cloned from mice (Rhcg and Rhbg) and humans (RhCG and RhBG) [4].
  • Rhbg and its human analog (RhBG) are expressed mainly in liver, skin and the kidney tubules [4].
 

Anatomical context of Rhbg

 

Analytical, diagnostic and therapeutic context of Rhbg

  • Here, we report the molecular cloning and biochemical characterization of Rh type B glycoproteins, human RhBG and mouse Rhbg, two new members of the Rh family with distinct tissue specificities [1].
  • Northern blot and in situ hybridization revealed that RHBG and Rhbg are predominantly expressed in liver, kidney, and skin, the specialized organs involving ammonia genesis, excretion, or secretion [1].

References

  1. Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals. Liu, Z., Peng, J., Mo, R., Hui, C., Huang, C.H. J. Biol. Chem. (2001) [Pubmed]
  2. Genetic ablation of Rhbg in the mouse does not impair renal ammonium excretion. Chambrey, R., Goossens, D., Bourgeois, S., Picard, N., Bloch-Faure, M., Leviel, F., Geoffroy, V., Cambillau, M., Colin, Y., Paillard, M., Houillier, P., Cartron, J.P., Eladari, D. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  3. Characteristics of renal Rhbg as an NH4(+) transporter. Nakhoul, N.L., Dejong, H., Abdulnour-Nakhoul, S.M., Boulpaep, E.L., Hering-Smith, K., Hamm, L.L. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  4. Non-erythroid Rh glycoproteins: a putative new family of mammalian ammonium transporters. Nakhoul, N.L., Hamm, L.L. Pflugers Arch. (2004) [Pubmed]
 
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