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Gene Review

Rad18  -  RAD18 homolog (S. cerevisiae)

Mus musculus

Synonyms: 2810024C04Rik, E3 ubiquitin-protein ligase RAD18, Postreplication repair protein RAD18, Rad18sc, mRAD18Sc
 
 
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Disease relevance of Rad18

  • These cells had almost the same growth rate as wild-type cells and manifested phenotypes similar to those of human cells expressing mutant Rad18 protein: hypersensitivity to multiple DNA damaging agents and a defect in postreplication repair [1].
  • Moreover, the elevated sensitivity of the Rad18(-/-) cells was also observed with adenovirus [2].
 

High impact information on Rad18

References

  1. Enhanced genomic instability and defective postreplication repair in RAD18 knockout mouse embryonic stem cells. Tateishi, S., Niwa, H., Miyazaki, J., Fujimoto, S., Inoue, H., Yamaizumi, M. Mol. Cell. Biol. (2003) [Pubmed]
  2. Effect of DNA repair protein Rad18 on viral infection. Lloyd, A.G., Tateishi, S., Bieniasz, P.D., Muesing, M.A., Yamaizumi, M., Mulder, L.C. PLoS Pathog. (2006) [Pubmed]
  3. Characterization of mRAD18Sc, a mouse homolog of the yeast postreplication repair gene RAD18. van der Laan, R., Roest, H.P., Hoogerbrugge, J.W., Smit, E.M., Slater, R., Baarends, W.M., Hoeijmakers, J.H., Grootegoed, J.A. Genomics (2000) [Pubmed]
 
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