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Gene Review:

Grk5 - G protein-coupled receptor kinase 5

Rattus norvegicus

Synonyms: G protein-coupled receptor kinase GRK5, Gprk5

Penela, P. et al., Ishizaka, N. et al., Nagayama, Y. et al.

Ishizaka, Alexander, Laursen, Kai, Fukui, Oppermann, Lefkowitz, Lyons, Griendling,

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Disease relevance of Gprk5

G protein-coupled receptor kinase 5 in cultured vascular smooth muscle cells and rat aorta. Regulation by angiotensin II and hypertension [1].

High impact information on Gprk5

These alterations are selective, as beta-adrenergic receptors or other G protein-coupled receptor regulatory proteins, such as G protein-coupled receptor kinase 5 or beta-arrestin-1, display a different pattern of expression changes in the hypothyroid animals [2].

Anatomical context of Gprk5

Expression and regulation of G protein-coupled receptor kinase 5 and beta-arrestin-1 in rat thyroid FRTL5 cells [3].

References

G protein-coupled receptor kinase 5 in cultured vascular smooth muscle cells and rat aorta. Regulation by angiotensin II and hypertension. Ishizaka, N., Alexander, R.W., Laursen, J.B., Kai, H., Fukui, T., Oppermann, M., Lefkowitz, R.J., Lyons, P.R., Griendling, K.K. J. Biol. Chem. (1997) [Pubmed]
Effect of hypothyroidism on G protein-coupled receptor kinase 2 expression levels in rat liver, lung, and heart. Penela, P., Barradas, M., Alvarez-Dolado, M., Muñoz, A., Mayor, F. Endocrinology (2001) [Pubmed]
Expression and regulation of G protein-coupled receptor kinase 5 and beta-arrestin-1 in rat thyroid FRTL5 cells. Nagayama, Y., Tanaka, K., Namba, H., Yamashita, S., Niwa, M. Thyroid (1996) [Pubmed]

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AgaP_AGAP004117	Anopheles gambiae str. PEST
GRK5	Bos taurus
grk-1	Caenorhabditis elegans
GRK5	Canis lupus familiaris
Gprk2	Drosophila melanogaster
GRK5	Gallus gallus
GRK5	Homo sapiens
LOC100427251	Macaca mulatta
Grk5	Mus musculus
GRK5	Pan troglodytes
LOC100497344	Xenopus (Silurana) tropicalis

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