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Ago2  -  argonaute RISC catalytic component 2

Rattus norvegicus

Synonyms: Argonaute RISC catalytic component 2, Argonaute2, Eif2c2, Eukaryotic translation initiation factor 2C 2, GERp95, ...
 
 
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High impact information on Eif2c2

  • Genetic studies suggest that homologs of GERp95 are components of signaling pathways that regulate cellular differentiation, development, and RNA interference [1].
  • GERp95 (Golgi-endoplasmic reticulum protein 95 kDa) is part of a large family of highly conserved proteins found in all metazoans and the fission yeast Schizosaccharomyces pombe [1].
  • Inhibition of Hsp90 activity with geldanamycin or radicicol resulted in rapid degradation of newly synthesized GERp95 [1].
  • These results indicate that GERp95 engages an Hsp90 chaperone complex prior to association with intracellular membranes [1].
  • Glutathione S-transferase-GERp95 fusions were expressed in transfected cells, and proteins that bound to GERp95 were co-purified using glutathione-agarose beads [1].
 

Biological context of Eif2c2

 

Anatomical context of Eif2c2

  • It has recently been determined that plant and Drosophila homologues of GERp95 are important for controlling the differentiation of stem cells (Bohmert et al., 1998; Cox et al., 1998; Moussian et al., 1998) [2].
  • Thus, we report that the GERp95 protein is functionally required for RNAi targeting NPY in rat PC12 cells [3].

References

  1. GERp95 belongs to a family of signal-transducing proteins and requires Hsp90 activity for stability and Golgi localization. Tahbaz, N., Carmichael, J.B., Hobman, T.C. J. Biol. Chem. (2001) [Pubmed]
  2. GERp95, a membrane-associated protein that belongs to a family of proteins involved in stem cell differentiation. Cikaluk, D.E., Tahbaz, N., Hendricks, L.C., DiMattia, G.E., Hansen, D., Pilgrim, D., Hobman, T.C. Mol. Biol. Cell (1999) [Pubmed]
  3. Characterization of RNA interference in rat PC12 cells: requirement of GERp95. Thonberg, H., Schéele, C.C., Dahlgren, C., Wahlestedt, C. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
 
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