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Nek7  -  NIMA (never in mitosis gene a)-related...

Mus musculus

Synonyms: 2810460C19Rik, AU020186, Never in mitosis A-related kinase 7, NimA-related protein kinase 7, Serine/threonine-protein kinase Nek7
 
 
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High impact information on Nek7

  • Nek6 (314AA) and Nek7 (303AA), 76% identical, have little noncatalytic sequence but bind to the carboxyl-terminal noncatalytic tail of Nercc1/Nek9, a NIMA family protein kinase that is activated in mitosis [1].
  • The related murine kinases, Nek6 and Nek7, display distinct patterns of expression [2].
 

Biological context of Nek7

  • Nek6 and Nek7 are evolutionarily conserved murine kinases structurally related to the Aspergillus mitotic-regulator NIMA (Genomics 68 (2000) 187) [2].
 

Analytical, diagnostic and therapeutic context of Nek7

References

  1. A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. Belham, C., Roig, J., Caldwell, J.A., Aoyama, Y., Kemp, B.E., Comb, M., Avruch, J. J. Biol. Chem. (2003) [Pubmed]
  2. The related murine kinases, Nek6 and Nek7, display distinct patterns of expression. Feige, E., Motro, B. Mech. Dev. (2002) [Pubmed]
  3. Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA. Kandli, M., Feige, E., Chen, A., Kilfin, G., Motro, B. Genomics (2000) [Pubmed]
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