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Gene Review: 

Nek6  -  NIMA (never in mitosis gene a)-related...

Mus musculus

Synonyms: 1300007C09Rik, Never in mitosis A-related kinase 6, NimA-related protein kinase 6, Serine/threonine-protein kinase Nek6
 
 
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High impact information on Nek6

  • The related murine kinases, Nek6 and Nek7, display distinct patterns of expression [1].
  • In contrast to the other documented NIMA-related kinases, Nek6/7 and F19H6.1 harbor their catalytic domain in the C-terminus of the protein [2].
  • Interestingly, Nek6 and Nek7 are also highly similar to the F19H6.1 protein kinase of Caenorhabditis elegans (76 and 73% amino acid identity in the kinase domain, respectively), and phylogenetic analysis suggests that these three proteins constitute a novel subfamily within the NIMA family of serine/threonine kinases [2].
 

Biological context of Nek6

  • Nek6 and Nek7 are evolutionarily conserved murine kinases structurally related to the Aspergillus mitotic-regulator NIMA (Genomics 68 (2000) 187) [1].
 

Analytical, diagnostic and therapeutic context of Nek6

References

  1. The related murine kinases, Nek6 and Nek7, display distinct patterns of expression. Feige, E., Motro, B. Mech. Dev. (2002) [Pubmed]
  2. Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA. Kandli, M., Feige, E., Chen, A., Kilfin, G., Motro, B. Genomics (2000) [Pubmed]
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