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Gene Review

Smad5  -  SMAD family member 5

Rattus norvegicus

Synonyms: MAD homolog 5, Madh5, Mothers against DPP homolog 5, Mothers against decapentaplegic homolog 5, SMAD 5
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High impact information on Smad5

  • Müllerian duct regression can also be inhibited or accelerated by siRNA targeting Smad8 and Smad5, respectively [1].
  • For example, Smad1 and Smad5 were highly expressed in proliferating chondrocytes and in those chondrocytes that are undergoing maturation [2].
  • The intracellular signaling molecules Smad2 and Smad5 mRNA expressions were not changed under these conditions [3].
  • The combination of OP-1 and CNP further stimulated the OP-1-induced Smad5 phosphorylation [4].
  • The data show that serine residues of the linker region of Smad5 reduce spontaneous transcriptional activity and that NGF-activated Erk does not antagonise BMP signalling at this site [5].


  1. Müllerian inhibiting substance regulates its receptor/SMAD signaling and causes mesenchymal transition of the coelomic epithelial cells early in Müllerian duct regression. Zhan, Y., Fujino, A., MacLaughlin, D.T., Manganaro, T.F., Szotek, P.P., Arango, N.A., Teixeira, J., Donahoe, P.K. Development (2006) [Pubmed]
  2. Localization of Smads, the TGF-beta family intracellular signaling components during endochondral ossification. Sakou, T., Onishi, T., Yamamoto, T., Nagamine, T., Sampath, T., Ten Dijke, P. J. Bone Miner. Res. (1999) [Pubmed]
  3. Osteogenic protein-1 and interleukin-6 with its soluble receptor synergistically stimulate rat osteoblastic cell differentiation. Yeh, L.C., Zavala, M.C., Lee, J.C. J. Cell. Physiol. (2002) [Pubmed]
  4. C-type natriuretic peptide enhances osteogenic protein-1-induced osteoblastic cell differentiation via Smad5 phosphorylation. Yeh, L.C., Zavala, M.C., Lee, J.C. J. Cell. Biochem. (2006) [Pubmed]
  5. Bone morphogenetic protein signalling in NGF-stimulated PC12 cells. Althini, S., Usoskin, D., Kylberg, A., ten Dijke, P., Ebendal, T. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
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