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Gene Review

Camkk1  -  calcium/calmodulin-dependent protein...

Rattus norvegicus

Synonyms: CaM-KK 1, CaM-KK alpha, CaM-kinase IV kinase, CaM-kinase kinase 1, CaM-kinase kinase alpha, ...
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Disease relevance of Camkk1


High impact information on Camkk1


Biological context of Camkk1


Anatomical context of Camkk1


Associations of Camkk1 with chemical compounds


Enzymatic interactions of Camkk1

  • Present study revealed that CaMKK also phosphorylated CaM kinase IV associated with the activation of its activity [14].

Regulatory relationships of Camkk1


Other interactions of Camkk1


Analytical, diagnostic and therapeutic context of Camkk1


  1. Purification and characterization of Ca2+/calmodulin-dependent protein kinase IV kinase from rat brain. Okuno, S., Kitani, T., Fujisawa, H. J. Biochem. (1994) [Pubmed]
  2. Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway. Yano, S., Tokumitsu, H., Soderling, T.R. Nature (1998) [Pubmed]
  3. The role of calcium/calmodulin-dependent protein kinase cascade in glucose upregulation of insulin gene expression. Yu, X., Murao, K., Sayo, Y., Imachi, H., Cao, W.M., Ohtsuka, S., Niimi, M., Tokumitsu, H., Inuzuka, H., Wong, N.C., Kobayashi, R., Ishida, T. Diabetes (2004) [Pubmed]
  4. A single amino acid difference between alpha and beta Ca2+/calmodulin-dependent protein kinase kinase dictates sensitivity to the specific inhibitor, STO-609. Tokumitsu, H., Inuzuka, H., Ishikawa, Y., Kobayashi, R. J. Biol. Chem. (2003) [Pubmed]
  5. Activation of calcium/calmodulin-dependent protein kinase IV in long term potentiation in the rat hippocampal CA1 region. Kasahara, J., Fukunaga, K., Miyamoto, E. J. Biol. Chem. (2001) [Pubmed]
  6. Substrate recognition by Ca2+/Calmodulin-dependent protein kinase kinase. Role of the arg-pro-rich insert domain. Tokumitsu, H., Takahashi, N., Eto, K., Yano, S., Soderling, T.R., Muramatsu, M. J. Biol. Chem. (1999) [Pubmed]
  7. Evidence for the existence of Ca2+/calmodulin-dependent protein kinase IV kinase isoforms in rat brain. Okuno, S., Kitani, T., Fujisawa, H. J. Biochem. (1996) [Pubmed]
  8. Demonstration of a Ca2+/calmodulin dependent protein kinase cascade in the hog heart. Uemura, A., Naito, Y., Matsubara, T., Hotta, N., Hidaka, H. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  9. Requirement of brain extract for the activity of brain calmodulin-dependent protein kinase IV expressed in Escherichia coli. Okuno, S., Fujisawa, H. J. Biochem. (1993) [Pubmed]
  10. Regulation of axonal extension and growth cone motility by calmodulin-dependent protein kinase I. Wayman, G.A., Kaech, S., Grant, W.F., Davare, M., Impey, S., Tokumitsu, H., Nozaki, N., Banker, G., Soderling, T.R. J. Neurosci. (2004) [Pubmed]
  11. Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase. Hsu, L.S., Tsou, A.P., Chi, C.W., Lee, C.H., Chen, J.Y. J. Biomed. Sci. (1998) [Pubmed]
  12. Distribution of Ca2+/calmodulin-dependent protein kinase kinase alpha in the rat central nervous system: an immunohistochemical study. Nakamura, Y., Okuno, S., Kitani, T., Otake, K., Sato, F., Fujisawa, H. Neurosci. Lett. (1996) [Pubmed]
  13. Purification and characterization of Ca2+/calmodulin-dependent protein kinase kinase beta from rat cerebellum. Okuno, S., Kitani, T., Fujisawa, H. J. Biochem. (1997) [Pubmed]
  14. Ca2+/calmodulin-dependent protein kinase kinase cascade. Sugita, R., Mochizuki, H., Ito, T., Yokokura, H., Kobayashi, R., Hidaka, H. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  15. Cloning, characterization and expression of two alternatively splicing isoforms of Ca2+/calmodulin-dependent protein kinase I gamma in the rat brain. Nishimura, H., Sakagami, H., Uezu, A., Fukunaga, K., Watanabe, M., Kondo, H. J. Neurochem. (2003) [Pubmed]
  16. Localization of the mRNAs for two isoforms of Ca2+/calmodulin-dependent protein kinase kinases in the adult rat brain. Sakagami, H., Saito, S., Kitani, T., Okuno, S., Fujisawa, H., Kondo, H. Brain Res. Mol. Brain Res. (1998) [Pubmed]
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