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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

Tg(KRT5-cre)1Tak  -  transgene insertion 1, Junji Takeda

Mus musculus

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Disease relevance of Tg(KRT5-cre)1Tak

  • Surprisingly, however, the K5Cre(+/+) papillomas displayed an accelerated tendency to malignant progression; in addition, the frequency of malignant transformation of the papillomas is significantly enhanced [1].
  • Fostering the K5Cre(+/+) pups to wild-type mothers results in normal weight gain, suggesting a maternal defect in milk production [1].
 

High impact information on Tg(KRT5-cre)1Tak

  • To distinguish primary from secondary consequences of beta1 integrin loss, we compared epidermal beta1 deletion at E14.5 via K5Cre and 4-hydroxy-tamoxifen induced deletion in adulthood via K14CreER [2].
  • As reported previously, there was dermo-epidermal splitting, inflammation, reduced proliferation, and hair follicle and sebaceous gland loss in 30-d-old K5Cre beta1-null mice [2].
  • Here we analyzed keratinocytes of the female K5-Cre: Pig-a flox/+ mice with heterozygous knockout of Pig-a. These cells exhibited the mosaic pattern of GPI-anchor positive and negative expression typical of random inactivation of the X chromosome [3].
  • In conclusion, we discovered a unique phenotype associated with the K5Cre(+/+) transgenic line [1].
  • No difference was observed in the time to onset of papilloma formation, the number of papillomas and the average papilloma volume between the Tg . AC(+/-) K5Cre(+/+) mice and their corresponding controls [1].
 

Biological context of Tg(KRT5-cre)1Tak

  • However, constitutive recombination between loxP sites transmitted by the sperm took place when the mother possessed the K5Cre transgene, even when the transgene was absent in the progeny [4].
  • Our results highlight the context-dependent effects of beta1 integrin deletion and suggest that inflammation may be responsible for some of the K5Cre beta1-null phenotype [2].
  • The keratin 5-Cre recombinase (K5Cre) transgenic mouse line has been used to generate skin specific gene deletions [1].
 

Anatomical context of Tg(KRT5-cre)1Tak

  • When the K5Cre(+/+) mammary glands were examined, we not only found a significant decrease in the number of mammary branches in the virgin females, but also a greater number of quiescent alveoli units in the lactating glands [1].
 

Other interactions of Tg(KRT5-cre)1Tak

References

  1. Homozygous K5Cre transgenic mice have wavy hair and accelerated malignant progression in a murine model of skin carcinogenesis. Chan, E.L., Peace, B.E., Toney, K., Kader, S.A., Pathrose, P., Collins, M.H., Waltz, S.E. Mol. Carcinog. (2007) [Pubmed]
  2. Different consequences of beta1 integrin deletion in neonatal and adult mouse epidermis reveal a context-dependent role of integrins in regulating proliferation, differentiation, and intercellular communication. López-Rovira, T., Silva-Vargas, V., Watt, F.M. J. Invest. Dermatol. (2005) [Pubmed]
  3. Rapid compensation for glycosylphosphatidylinositol anchor deficient keratinocytes after birth: visualization of glycosylphosphatidylinositol-anchored proteins in situ. Gao, X.H., Kondoh, G., Tarutani, M., Hara, M., Inoue, S., Nakanishi, T., Okabe, M., Yamaguchi, Y., Yoshikawa, K., Itami, S., Takeda, J. J. Invest. Dermatol. (2002) [Pubmed]
  4. A keratin K5Cre transgenic line appropriate for tissue-specific or generalized Cre-mediated recombination. Ramirez, A., Page, A., Gandarillas, A., Zanet, J., Pibre, S., Vidal, M., Tusell, L., Genesca, A., Whitaker, D.A., Melton, D.W., Jorcano, J.L. Genesis (2004) [Pubmed]
 
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