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Gene Review

SNORD21  -  small nucleolar RNA, C/D box 21

Homo sapiens

Synonyms: RNU21, U21
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Disease relevance of SNORD21

  • We identify and characterize a protein from HHV-7, U21, that binds to and diverts properly folded class I molecules to a lysosomal compartment [1].
  • We report that (i) both nectin2alpha and -delta served as receptors for the entry of HSV-1 mutant viruses HSV-1(U10) and -(U21) and AP7(r) that carry the Leu25Pro substitution in gD but not for HSV-1 mutants U30 and R5000 that carry the Ser140 or Ala185 substitution in gD [2].

High impact information on SNORD21


Biological context of SNORD21

  • Remarkably, U21 contains a long stretch (13 nt.) of complementarity to a highly conserved sequence in 28S rRNA [4].
  • The rod cGMP PDE alpha-, beta-, and gamma-subunit genes map to bovine syntenic groups U22, U15 (chromosome 6), and U21 (chromosome 19), respectively [5].
  • Telemedicine activities in underserved communities were reviewed as part of the Universitas 21 (U21) e-health project [6].
  • Running velocities corresponding to all lactate concentrations showed no significant differences at all age groups, but heart rates in soccer players in the U21 and U19 age groups were significantly lower than in the U17 age group [7].


  1. A human herpesvirus 7 glycoprotein, U21, diverts major histocompatibility complex class I molecules to lysosomes. Hudson, A.W., Howley, P.M., Ploegh, H.L. J. Virol. (2001) [Pubmed]
  2. Nectin2alpha (PRR2alpha or HveB) and nectin2delta are low-efficiency mediators for entry of herpes simplex virus mutants carrying the Leu25Pro substitution in glycoprotein D. Lopez, M., Cocchi, F., Menotti, L., Avitabile, E., Dubreuil, P., Campadelli-Fiume, G. J. Virol. (2000) [Pubmed]
  3. U24, a novel intron-encoded small nucleolar RNA with two 12 nt long, phylogenetically conserved complementarities to 28S rRNA. Qu, L.H., Henry, Y., Nicoloso, M., Michot, B., Azum, M.C., Renalier, M.H., Caizergues-Ferrer, M., Bachellerie, J.P. Nucleic Acids Res. (1995) [Pubmed]
  4. U21, a novel small nucleolar RNA with a 13 nt. complementarity to 28S rRNA, is encoded in an intron of ribosomal protein L5 gene in chicken and mammals. Qu, L.H., Nicoloso, M., Michot, B., Azum, M.C., Caizergues-Ferrer, M., Renalier, M.H., Bachellerie, J.P. Nucleic Acids Res. (1994) [Pubmed]
  5. Syntenic assignments of visual transduction genes in cattle. Gallagher, D.S., Womack, J.E., Baehr, W., Pittler, S.J. Genomics (1992) [Pubmed]
  6. E-health and the Universitas 21 organization: 2. Telemedicine and underserved populations. Wootton, R., Jebamani, L.S., Dow, S.A. Journal of telemedicine and telecare. (2005) [Pubmed]
  7. Running velocities and heart rates at fixed blood lactate concentrations in young soccer players. Guner, R., Kunduracioglu, B., Ulkar, B. Advances in therapy. (2006) [Pubmed]
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