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Gene Review

EGFR  -  epidermal growth factor receptor

Macaca mulatta

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High impact information on EGFR


Biological context of EGFR

  • The stromal cells of both lobes did not show EGF-r. This study revealed that each prostatic lobe contains specific binding sites for EGF, indicating a biological difference between the two lobes of the prostate of the rhesus monkey [4].

Anatomical context of EGFR


Associations of EGFR with chemical compounds


Other interactions of EGFR

  • These results demonstrate that increases in TGF alpha and EGFR gene expression, specific to the neuroendocrine brain, occur during developmental phases in which gonadotropin output is also elevated--most noticeably at the time of puberty.(ABSTRACT TRUNCATED AT 400 WORDS)[2]

Analytical, diagnostic and therapeutic context of EGFR

  • DNA fragments complementary to the coding regions of the rhesus monkey TGF alpha, EGFR and LHRH genes were cloned by reverse transcription-polymerase chain reaction (RT-PCR), sequenced and used to prepare monkey-specific antisense RNA probes [2].


  1. Epidermal growth factor family in rhesus monkey uterus during the menstrual cycle and early pregnancy. Yue, Z.P., Yang, Z.M., Li, S.J., Wang, H.B., Harper, M.J. Mol. Reprod. Dev. (2000) [Pubmed]
  2. Developmental expression of the genes encoding transforming growth factor alpha and its receptor in the hypothalamus of female rhesus macaques. Ma, Y.J., Costa, M.E., Ojeda, S.R. Neuroendocrinology (1994) [Pubmed]
  3. Characterization of epidermal growth factor receptor in testis, epididymis and vas deferens of non-human primates. Radhakrishnan, B., Suarez-Quian, C.A. J. Reprod. Fertil. (1992) [Pubmed]
  4. Immunohistochemical localization of the epidermal growth factor-receptor in rhesus-monkey prostate. Wakui, S., Furusato, M., Sasaki, S., Masaoka, T., Ushigome, S., Aizawa, S. Anatomia, histologia, embryologia. (1996) [Pubmed]
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