High impact information on EGFR

• A high level of EGF, and EGFR staining was maintained on days 16, 20, and 25 of the menstrual cycle [1].
• EGF, TGFalpha, HB-EGF, AR, and EGFR were mainly localized in glandular and luminal epithelium [1].
• This study examines immunohistochemically the presence of EGF, TGFalpha, HB-EGF, AR, and EGFR, members of the EGF family in the monkey uterus during the menstrual cycle and early pregnancy [1].
• In contrast to the pronounced alterations in hypothalamic TGF alpha/EGFR gene expression observed during sexual development, LHRH mRNA levels did not vary significantly during this time [2].
• Characterization of epidermal growth factor receptor in testis, epididymis and vas deferens of non-human primates [3].

Biological context of EGFR

• The stromal cells of both lobes did not show EGF-r. This study revealed that each prostatic lobe contains specific binding sites for EGF, indicating a biological difference between the two lobes of the prostate of the rhesus monkey [4].

Anatomical context of EGFR

• Hybridization histochemistry revealed the presence of both TGF alpha and EGFR mRNAs in cells scattered throughout the hypothalamus, but more predominantly in the median eminence, suprachiasmatic nuclei, optic chiasm and cells along the wall of the third ventricle [2].
• The presence of the epidermal growth factor receptor (EGFR) in testis, epididymis and vas deferens of monkeys was demonstrated using a polyclonal antibody (RK2) raised against a peptide-specific sequence of the intracellular domain of the human EGFR [3].
• The distribution patterns of EGF-r in the prostatic epithelial cells were quite different between the cranial and caudal lobes [4].

Associations of EGFR with chemical compounds

• Epidermal growth-factor receptor (EGF-r), a membrane-bound glycoprotein activated by EGF, is important in maintaining the integrity and function of the prostate [4].

Other interactions of EGFR

• These results demonstrate that increases in TGF alpha and EGFR gene expression, specific to the neuroendocrine brain, occur during developmental phases in which gonadotropin output is also elevated--most noticeably at the time of puberty.(ABSTRACT TRUNCATED AT 400 WORDS)[2]

Analytical, diagnostic and therapeutic context of EGFR

• DNA fragments complementary to the coding regions of the rhesus monkey TGF alpha, EGFR and LHRH genes were cloned by reverse transcription-polymerase chain reaction (RT-PCR), sequenced and used to prepare monkey-specific antisense RNA probes [2].

References