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RPS6KA2  -  ribosomal protein S6 kinase, 90kDa,...

Homo sapiens

Synonyms: 90 kDa ribosomal protein S6 kinase 2, HU-2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, MAPKAP kinase 1c, ...
 
 
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Disease relevance of RPS6KA2

  • Re-expression of RPS6KA2 in ovarian cancer cell lines suppressed colony formation [1].
  • Immunohistochemical study revealed that the expressions of both extracellular signal-regulated kinases (ERK) and ribosomal protein S6 kinase (RSK), two of the key genes in the MAPK pathway, were remarkably induced, which was closely correlated to that of collagen types I and III during the development of hepatic fibrosis [2].
  • Between February 2001 and January 2002, an increase in the number of Klebsiella pneumoniae isolates with reduced susceptibility to expanded-spectrum cephalosporins (RSKp) was detected in the neonatal unit of the Juan Canalejo Hospital, and 21 patients were either colonized or infected by the bacterial isolates [3].
 

High impact information on RPS6KA2

 

Biological context of RPS6KA2

 

Anatomical context of RPS6KA2

  • Hemagglutinin epitope-tagged RSK3 was expressed in transiently transfected COS cells [6].
  • RSK3 mRNA was widely expressed (but was predominant in lung and skeletal muscle) [6].
  • These results provide evidence that RSK3 is a third distinct isoform of pp90rsk which translocates to the cell nucleus, phosphorylates potential nuclear targets, and may have a unique upstream activator [6].
  • Finally, we used affinity-purified RSK3 antibodies to demonstrate by immunofluorescence that endogenous RSK3 undergoes serum-stimulated nuclear translocation in cultured HeLa cells [6].
  • An Ab to the protein kinase p90RSK2 (also referred to as MAPKAP-K1b, or p90rsk) immunoprecipitated the active 90-kDa kinase from lysates of stimulated neutrophils [9].
 

Associations of RPS6KA2 with chemical compounds

  • Results from our recent work show that sodium salicylate at pharmacological concentrations inhibits C/EBPbeta binding to COX-2 promoter by direct inhibition of p90 ribosomal S6 kinase (RSK) [7].
  • Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser/Thr kinase, RSK [10].
 

Enzymatic interactions of RPS6KA2

  • Furthermore, MAPKs in RSK3 immunoprecipitates were phosphorylated by purified MEK1; however, RSK3 kinase activity was unaffected [11].
 

Other interactions of RPS6KA2

  • Both dephosphorylated (from quiescent cells) and phosphorylated (from stimulated cells) MAPKs were associated with RSK2 and RSK3 [11].
  • In contrast, RSK3 activity was not affected by exposure to ERK1 [11].
  • These data establish that the renaturable 90-kDa protein kinase is p90RSK2 and that CREB may be a substrate for this enzyme in these cells [9].
  • Because the homozygous deletion might affect the expression of nearby genes, we analyzed the expression of the two closest known genes flanking the deletion, RNASE6PL and RSK-3 [12].

References

  1. RPS6KA2, a putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer. Bignone, P.A., Lee, K.Y., Liu, Y., Emilion, G., Finch, J., Soosay, A.E., Charnock, F.M., Beck, S., Dunham, I., Mungall, A.J., Ganesan, T.S. Oncogene (2007) [Pubmed]
  2. Differential expression genes analyzed by cDNA array in the regulation of rat hepatic fibrogenesis. Qiang, H., Lin, Y., Zhang, X., Zeng, X., Shi, J., Chen, Y.X., Yang, M.F., Han, Z.G., Xie, W.F. Liver Int. (2006) [Pubmed]
  3. Risk factors for colonization and infection in a hospital outbreak caused by a strain of Klebsiella pneumoniae with reduced susceptibility to expanded-spectrum cephalosporins. Cartelle, M., del Mar Tomas, M., Pertega, S., Beceiro, A., Dominguez, M.A., Velasco, D., Molina, F., Villanueva, R., Bou, G. J. Clin. Microbiol. (2004) [Pubmed]
  4. Nuclear actin and myosin I are required for RNA polymerase I transcription. Philimonenko, V.V., Zhao, J., Iben, S., Dingová, H., Kyselá, K., Kahle, M., Zentgraf, H., Hofmann, W.A., de Lanerolle, P., Hozák, P., Grummt, I. Nat. Cell Biol. (2004) [Pubmed]
  5. The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. Shahbazian, D., Roux, P.P., Mieulet, V., Cohen, M.S., Raught, B., Taunton, J., Hershey, J.W., Blenis, J., Pende, M., Sonenberg, N. EMBO J. (2006) [Pubmed]
  6. RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation. Zhao, Y., Bjørbaek, C., Weremowicz, S., Morton, C.C., Moller, D.E. Mol. Cell. Biol. (1995) [Pubmed]
  7. Transcription-based COX-2 inhibition: A therapeutic strategy. Wu, K.K. Thromb. Haemost. (2006) [Pubmed]
  8. Human rsk isoforms: cloning and characterization of tissue-specific expression. Moller, D.E., Xia, C.H., Tang, W., Zhu, A.X., Jakubowski, M. Am. J. Physiol. (1994) [Pubmed]
  9. Activation of p90RSK and cAMP response element binding protein in stimulated neutrophils: novel effects of the pyridinyl imidazole SB 203580 on activation of the extracellular signal-regulated kinase cascade. Lian, J.P., Huang, R., Robinson, D., Badwey, J.A. J. Immunol. (1999) [Pubmed]
  10. Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser/Thr kinase, RSK. Smith, J.A., Maloney, D.J., Clark, D.E., Xu, Y., Hecht, S.M., Lannigan, D.A. Bioorg. Med. Chem. (2006) [Pubmed]
  11. Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases. Zhao, Y., Bjorbaek, C., Moller, D.E. J. Biol. Chem. (1996) [Pubmed]
  12. A novel homozygous deletion at chromosomal band 6q27 in an ovarian cancer cell line delineates the position of a putative tumor suppressor gene. Lin, H., Morin, P.J. Cancer Lett. (2001) [Pubmed]
 
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