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Gene Review:

Capn10 - calpain 10

Rattus norvegicus

Synonyms: CANP 10, Calcium-activated neutral proteinase 10, Calpain-10

Muramatsu, Y. et al., Wu, S.H. et al.

Wu, Lu, Dong, Zhou, He, Chen,

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Disease relevance of Capn10

Capn10, a candidate gene responsible for type 2 diabetes mellitus in the OLETF rat [1].

High impact information on Capn10

Pretreatment of the cells with calcium inhibitor SK&F96365 inhibited the LXA4-induced apoptosis, levels of [Ca2+]i, expression of calpain 10 and Smac [2].
In conclusion, LXA4 at high concentrations induced apoptosis of renal interstitial fibroblasts via [Ca2+]i-dependent upregulation of calpain 10 and Smac expression [2].
Comparative mapping between human and rat indicated that the Nidd8/of genomic region, near D9rat21 on rat chromosome 9, contains the calpain10 (Capn10) gene, which is putative type 2 diabetes-susceptibility gene in humans [1].
In this study, we found no difference in Capn10 mRNA expression in the heart, liver, skeletal muscle and pancreas between OLETF and F344 rats at 5 and 10 weeks of age [1].
This SNP was deduced to substitute serine (OLETF) for glycine (F344 and LETO) at the 195 amino acid residue within the protease domain of rat Capn10 [1].

Biological context of Capn10

However, we found a single nucleotide polymorphism (SNP) (A/A genotype in OLETF and G/G genotype in F344 and LETO rats) at the base 583 downstream from the translation start site in the rat Capn10 cDNA sequence [1].

References

Capn10, a candidate gene responsible for type 2 diabetes mellitus in the OLETF rat. Muramatsu, Y., Taniguchi, Y., Kose, H., Matsumoto, K., Yamada, T., Sasaki, Y. IUBMB Life (2003) [Pubmed]
High dose of lipoxin A4 induces apoptosis in rat renal interstitial fibroblasts. Wu, S.H., Lu, C., Dong, L., Zhou, G.P., He, Z.G., Chen, Z.Q. Prostaglandins Leukot. Essent. Fatty Acids (2005) [Pubmed]

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