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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

epha4b  -  eph receptor A4b

Danio rerio

Synonyms: EphA3, SO:0000704, epha4, rtk2
 
 
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High impact information on epha4b

  • As gastrulation proceeds, both rtk1 and rtk2 are expressed within the axial hypoblast along the entire axis of the embryo [1].
  • Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization [2].
  • The transcription factors fli-1 and Nkx-2.5 are expressed asymmetrically in the precardiac mesoderm and subsequently in the heart; an Eph receptor, rtk2, and an adhesion protein, DM-GRASP, mark early asymmetries in visceral endoderm [3].

References

  1. Spatially regulated expression of three receptor tyrosine kinase genes during gastrulation in the zebrafish. Xu, Q., Holder, N., Patient, R., Wilson, S.W. Development (1994) [Pubmed]
  2. Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization. Lackmann, M., Oates, A.C., Dottori, M., Smith, F.M., Do, C., Power, M., Kravets, L., Boyd, A.W. J. Biol. Chem. (1998) [Pubmed]
  3. Regulation of left-right asymmetries in the zebrafish by Shh and BMP4. Schilling, T.F., Concordet, J.P., Ingham, P.W. Dev. Biol. (1999) [Pubmed]
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