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Gene Review

SRSF5  -  serine/arginine-rich splicing factor 5

Homo sapiens

Synonyms: Delayed-early protein HRS, HRS, Pre-mRNA-splicing factor SRP40, SFRS5, SRP40, ...
 
 
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Disease relevance of SFRS5

 

High impact information on SFRS5

  • The human SFRS5 gene was localized to human chromosome 14q24 by fluorescence in situ hybridization and PCR analysis of a human/hamster somatic cell hybrid panel [2].
  • SFRS5/SRp40 is a member of the serine/arginine (SR) protein family of regulators of alternative pre-mRNA splicing [2].
  • The high yield of chromatid-type aberrations observed in our experiments at low doses confirms the idea that the molecular mechanisms which underlie the HRS phenotype may differ from the classical mechanisms of radiation-induced aberration formation [1].
  • The quality of speech with the Provox2 voice prosthesis was analyzed using the HRS rating scale, the maximum phonation time (MPT), incidence of complications and the in situ lifetime [3].
  • RESULTS: The platelet count and HRS did not change during storage [4].

References

  1. Cytogenetic effects of low-dose radiation with different LET in human peripheral blood lymphocytes. Nasonova, E.A., Shmakova, N.L., Komova, O.V., Mel'nikova, L.A., Fadeeva, T.A., Krasavin, E.A., Ritter, S. Radiation and environmental biophysics (2006) [Pubmed]
  2. Expression analysis and chromosomal assignment of the human SFRS5/SRp40 gene. Snow, B.E., Heng, H.H., Shi, X.M., Zhou, Y., Du, K., Taub, R., Tsui, L.C., McInnes, R.R. Genomics (1997) [Pubmed]
  3. Voice rehabilitation with Provox2trade mark voice prosthesis following total laryngectomy for laryngeal and hypopharyngeal carcinoma. Terada, T., Saeki, N., Toh, K., Uwa, N., Sagawa, K., Takayasu, S., Sakagami, M. Auris, nasus, larynx (2007) [Pubmed]
  4. New methods showing in vitro changes of platelets. Rock, G., Freedman, M., Hamilton, C., Bormanis, J. Transfus. Apher. Sci. (2006) [Pubmed]
 
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