The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt

Table of contents

About

Terms

 

Gene Review: 

vox  -  ventral homeobox

Danio rerio

Synonyms: SO:0000704, vega1, zgc:136532
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on vox

  • In turn, vox and vent repress chordin expression, restricting its function as an antagonist of ventral fates to the dorsal side of the embryo [1].
  • In contrast, embryos that lack both vox and vent function have a dorsalized phenotype [1].
  • Functional and hierarchical interactions among zebrafish vox/vent homeobox genes [2].
  • Ved functions redundantly with vox/vega1 and vent/vega2 to restrict the organizer domain [3].
  • Expression of a Dha/Boz fused to the transcriptional activator VP16 repressed dorsal axis formation and the expression of organizer genes but led to the dorsal expansion of expression of the homeobox gene vox/vega1, indicating that Dha/Boz functions as a transcriptional repressor for dorsal axis formation [3].
 

Biological context of vox

  • The combined inhibition of ved, vox/vega1, and vent/vega2, by antisense morpholino injection, strongly dorsalized the embryos and elicited ventral expansion of organizer gene expression, compared with the effect of inhibiting each of these genes alone [3].

References

  1. The homeobox genes vox and vent are redundant repressors of dorsal fates in zebrafish. Imai, Y., Gates, M.A., Melby, A.E., Kimelman, D., Schier, A.F., Talbot, W.S. Development (2001) [Pubmed]
  2. Functional and hierarchical interactions among zebrafish vox/vent homeobox genes. Gilardelli, C.N., Pozzoli, O., Sordino, P., Matassi, G., Cotelli, F. Dev. Dyn. (2004) [Pubmed]
  3. A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok-mediated dorsal organizer formation in zebrafish. Shimizu, T., Yamanaka, Y., Nojima, H., Yabe, T., Hibi, M., Hirano, T. Mech. Dev. (2002) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities