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Gene Review: 

Ppp1r10  -  protein phosphatase 1, regulatory subunit 10

Rattus norvegicus

Synonyms: Cat53, Fb19, MHC class I region proline-rich protein CAT53, Phosphatase 1 nuclear targeting subunit, Pnuts, ...
 
 
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High impact information on Ppp1r10

  • PNUTS exhibited selective binding for poly(A) and poly(G) compared with poly(U) or poly(C) ribonucleotide homopolymers, with specificity being mediated by distinct regions within the domain rich in His and Gly and the domain containing the RGG motifs [1].
  • PNUTS is a ubiquitously expressed protein that exhibits a discreet nuclear compartmentalization and is colocalized with chromatin at distinct phases during mitosis [2].

References

  1. PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation. Kim, Y.M., Watanabe, T., Allen, P.B., Kim, Y.M., Lee, S.J., Greengard, P., Nairn, A.C., Kwon, Y.G. J. Biol. Chem. (2003) [Pubmed]
  2. Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit. Allen, P.B., Kwon, Y.G., Nairn, A.C., Greengard, P. J. Biol. Chem. (1998) [Pubmed]
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