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Gene Review

Slit1  -  slit homolog 1 (Drosophila)

Rattus norvegicus

Synonyms: Megf4, Multiple EGF-like domains protein 4, Multiple epidermal growth factor-like domains protein 4, Slit homolog 1 protein, Slit-1
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High impact information on Slit1

  • The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors [1].
  • Here we report that Slit, a secreted protein previously known for its role of repulsion in axon guidance and neuronal migration, can also inhibit leukocyte chemotaxis induced by chemotactic factors [1].
  • Conversely, inhibition of Slit-Robo interactions by Robo-Fc fusion proteins or by a dominant-negative Robo attenuates dendritic branching [2].
  • Regulation of cortical dendrite development by Slit-Robo interactions [2].
  • A basic conservation of cell migration guidance mechanisms in the nervous and immune systems was proposed when Slit, known for its role in axon guidance, was found to inhibit chemokine-induced leukocyte chemotaxis in vitro [3].

Biological context of Slit1

  • The splicing product, Slit1alpha, arises through alternative splicing at the C-terminus of Slit1, causing defects in the cysteine knot domain [4].
  • Thus, the results identify that Drm and Dan can interact with Slit proteins and act as inhibitors of monocyte chemotaxis, demonstrating a previously unidentified biological role for these proteins [5].
  • Robo, the receptor for the midline repellent Slit, is a member of the cell adhesion molecule (CAM) Ig superfamily [6].

Anatomical context of Slit1


Associations of Slit1 with chemical compounds

  • RESULTS: Slit lamp microscope observations indicated that curcumin at 0.002% (group C) delayed the onset and maturation of cataract [11].

Regulatory relationships of Slit1

  • It was reported that the signal from Robo is transmitted to a specific family of GTPase-activating proteins (GAPs) named Slit-Robo GAPs [9].

Other interactions of Slit1

  • Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding [6].

Analytical, diagnostic and therapeutic context of Slit1

  • Our results suggest that srGAP2, as a part of Slit-Robo pathway, plays an important role in the axonal regeneration after axotomy [9].


  1. The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors. Wu, J.Y., Feng, L., Park, H.T., Havlioglu, N., Wen, L., Tang, H., Bacon, K.B., Jiang Zh, n.u.l.l., Zhang Xc, n.u.l.l., Rao, Y. Nature (2001) [Pubmed]
  2. Regulation of cortical dendrite development by Slit-Robo interactions. Whitford, K.L., Marillat, V., Stein, E., Goodman, C.S., Tessier-Lavigne, M., Chédotal, A., Ghosh, A. Neuron (2002) [Pubmed]
  3. Modulation of inflammation by slit protein in vivo in experimental crescentic glomerulonephritis. Kanellis, J., Garcia, G.E., Li, P., Parra, G., Wilson, C.B., Rao, Y., Han, S., Smith, C.W., Johnson, R.J., Wu, J.Y., Feng, L. Am. J. Pathol. (2004) [Pubmed]
  4. Expression and function of Slit1alpha, a novel alternative splicing product for slit1. Tanno, T., Takenaka, S., Tsuyama, S. J. Biochem. (2004) [Pubmed]
  5. Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis. Chen, B., Blair, D.G., Plisov, S., Vasiliev, G., Perantoni, A.O., Chen, Q., Athanasiou, M., Wu, J.Y., Oppenheim, J.J., Yang, D. J. Immunol. (2004) [Pubmed]
  6. Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding. Liu, Z., Patel, K., Schmidt, H., Andrews, W., Pini, A., Sundaresan, V. Mol. Cell. Neurosci. (2004) [Pubmed]
  7. Spatiotemporal expression patterns of slit and robo genes in the rat brain. Marillat, V., Cases, O., Nguyen-Ba-Charvet, K.T., Tessier-Lavigne, M., Sotelo, C., Chédotal, A. J. Comp. Neurol. (2002) [Pubmed]
  8. Slit inhibition of retinal axon growth and its role in retinal axon pathfinding and innervation patterns in the diencephalon. Ringstedt, T., Braisted, J.E., Brose, K., Kidd, T., Goodman, C., Tessier-Lavigne, M., O'Leary, D.D. J. Neurosci. (2000) [Pubmed]
  9. Changes in mRNA of Slit-Robo GTPase-activating protein 2 following facial nerve transection. Madura, T., Yamashita, T., Kubo, T., Tsuji, L., Hosokawa, K., Tohyama, M. Brain Res. Mol. Brain Res. (2004) [Pubmed]
  10. Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. Itoh, A., Miyabayashi, T., Ohno, M., Sakano, S. Brain Res. Mol. Brain Res. (1998) [Pubmed]
  11. Effect of curcumin on galactose-induced cataractogenesis in rats. Suryanarayana, P., Krishnaswamy, K., Reddy, G.B. Mol. Vis. (2003) [Pubmed]
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