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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

UPF3A  -  UPF3 regulator of nonsense transcripts...

Homo sapiens

Synonyms: HUPF3A, Nonsense mRNA reducing factor 3A, RENT3A, Regulator of nonsense transcripts 3A, UPF3, ...
 
 
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High impact information on UPF3A

  • Like Y14 and Aly/REF, hUpf3 binds to spliced mRNAs specifically ( approximately 20 nucleotides) upstream of exon-exon junctions [1].
  • The mRNA export factors Aly/REF and TAP are also associated with nuclear hUpf3, indicating that hUpf3 is in mRNP complexes that are poised for nuclear export [1].
  • For mammalian NMD, current models propose a linear pathway that involves the splicing-dependent deposition of exon-junction complexes (EJCs) and the sequential action of the NMD factors UPF3, UPF2, and UPF1 [2].
  • We also show that P-hUPF1 forms distinct complexes containing different isoforms of hUPF3A [3].
  • We also demonstrate that Upf2p and Upf3p interact with eRF3, and that their ability to bind eRF3 correlates with their ability to complement the nonsense suppression phenotype [4].
 

Biological context of UPF3A

  • Moreover, by serving as an anchoring point for the factors Upf2 and Upf3, the EJC provides a direct link between splicing and nonsense-mediated mRNA decay [5].
 

Physical interactions of UPF3A

  • In mammals, PTCs are discriminated from physiological stop codons by a process thought to involve the splicing-dependent deposition of an exon junction complex (EJC), EJC-mediated recruitment of Upf3, and Upf2 binding to the N terminus of Upf3 [6].

References

  1. Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex. Kim, V.N., Kataoka, N., Dreyfuss, G. Science (2001) [Pubmed]
  2. Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements. Gehring, N.H., Kunz, J.B., Neu-Yilik, G., Breit, S., Viegas, M.H., Hentze, M.W., Kulozik, A.E. Mol. Cell (2005) [Pubmed]
  3. Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Ohnishi, T., Yamashita, A., Kashima, I., Schell, T., Anders, K.R., Grimson, A., Hachiya, T., Hentze, M.W., Anderson, P., Ohno, S. Mol. Cell (2003) [Pubmed]
  4. The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts. Wang, W., Czaplinski, K., Rao, Y., Peltz, S.W. EMBO J. (2001) [Pubmed]
  5. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. Le Hir, H., Gatfield, D., Izaurralde, E., Moore, M.J. EMBO J. (2001) [Pubmed]
  6. Y14 and hUpf3b form an NMD-activating complex. Gehring, N.H., Neu-Yilik, G., Schell, T., Hentze, M.W., Kulozik, A.E. Mol. Cell (2003) [Pubmed]
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